{"id":5010,"date":"2021-06-29T03:13:51","date_gmt":"2021-06-28T19:13:51","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5010"},"modified":"2021-06-29T03:13:51","modified_gmt":"2021-06-28T19:13:51","slug":"new-learning-discoveries-about-c4h4n2o","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5010","title":{"rendered":"New learning discoveries about C4H4N2O"},"content":{"rendered":"<p>Adding a certain compound to certain chemical reactions, such as: 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound  35344-95-7, <a href=\"https:\/\/www.ambeed.com\/products\/35344-95-7.html\">COA of Formula: C4H4N2O<\/a><\/p>\n<p>1-isopropyl-1H-pyrazole-4-carbaldehyde To a solution of lH-pyrazole-4-carbaldehyde (2.0 g, 21 mmol) and 2-iodopropane (5.32 g, 31.5 mmol) in DMF (10 mL) was added sodium hydride (60% dispersion in mineral oil, 0.83 g, 20.7 mmol) in one portion. The resulting mixture was stirred at room temperature for 2 hours, before being quenched with water and extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate and concentrated. The residue was purified by flash column chromatography on silica gel eluting with 0-50% EtO Ac\/heptane to obtain 1- isopropylpyrazole-4-carbaldehyde (1.2 g, 42% yield). 1H NMR (400 MHz, CDC13) delta 9.86 (s, 1H), 7.97 (s, 2H), 4.54 (p, \/ = 6.7 Hz, 1H), 1.55 (d, \/ = 6.7 Hz, 6H).<\/p>\n<p>If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2019191112&#038;F=0\">Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian K.; GEHLING, Victor S.; HARMANGE, Jean-Christophe; LAI, Tommy; LIANG, Jun; DRAGOVICH, Peter; ORTWINE, Dan; LABADIE, Sharada; ZHANG, Birong; KIEFER, Jim; WO2015\/135094; (2015); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[154,131],"tags":[145],"class_list":["post-5010","post","type-post","status-publish","format-standard","hentry","category-35344-95-7","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New learning discoveries about<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 35344-95-7, name is 1H-Pyrazole-4-carbaldehyde, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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