{"id":5008,"date":"2021-06-29T03:13:51","date_gmt":"2021-06-28T19:13:51","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5008"},"modified":"2021-06-29T03:13:51","modified_gmt":"2021-06-28T19:13:51","slug":"discovery-of-c4h7n3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5008","title":{"rendered":"Discovery of C4H7N3"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1192-21-8, Recommanded Product: 1-Methyl-1H-pyrazol-5-amine<\/a><\/p>\n

(3 S)-7-(2-Chloro-5-methylpyrimidin-4-yl)-3-methyl-2-((2-methylpyridin-3-yl)methyl)-3 ,4- dihydropyrrolo [1 ,2-a]pyrazin- 1 (2H)-one (118 mg, 0.31 mmol), i-methyl-i H-pyrazol-5 -amine (33.0 mg, 0.34 mmol), cesium carbonate (201 mg, 0.62 mmol) and BrettPhos 3rd generation pre-catalyst (14.01 mg, 0.02 mmol) were suspended in tert-butanol (5 mL) and de-gassed for 10 minutes. The reaction was heated to 80 \u00b0C for 18 hours under nitrogen. The mixture was cooled to room temperature, diluted with EtOAc (50 mL), washed with saturated aqueous sodium bicarbonate (10 mL) and the layers separated. The aqueousportion was washed with ethyl acetate (50 mL) and the combined organics were dried (sodium sulfate) and concentrated in vacuo to a brown gum (198 mg). The solid was taken up in DMSO (5 mL) and filtered. The crude product was purified by preparative HPLC (Waters XBridge Prep C18 OBD column, Sji silica, 30 mm diameter, 100 mm length), using decreasingly polar mixtures of water (containing 1percent NH3) and MeCN as eluents.Fractions containing the desired compound were evaporated to dryness to afford (3 S)-3 -methyl-7-(5 -methyl-2-(( i-methyl-i H-pyrazol-5 -yl)amino)pyrimidin-4-yl)-2-((2-methylpyridin-3 -yl)methyl)-3 ,4-dihydropyrrolo [1 ,2-a]pyrazin- 1 (2H)-one (74.0 mg,54.1 percent) as a white solid. ?H NMR (400 MHz, DMSO, 30 \u00b0C) 1.14 (3H, d), 2.32 (3H, s),3.68 (3H, s), 3.81 (1H, d), 4.16 – 4.27 (2H, m), 4.34 (1H, dd), 5.12 (1H, d), 6.26 (1H, d),7.20 (1H, dd), 7.27 (1H, d), 7.33 (1H, d), 7.58 – 7.7 (2H, m), 8.23 (1H, s), 8.35 (1H, d),9.06 (1H, s). mlz: ES+ [M+H]+ 442.<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n

Reference:
Patent; ASTRAZENECA AB; WARD, Richard, Andrew; GRAHAM, Mark, Andrew; SWALLOW, Steven; JONES, Clifford, David; (282 pag.)WO2016\/162325; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[191,131],"tags":[145],"class_list":["post-5008","post","type-post","status-publish","format-standard","hentry","category-1192-21-8","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nDiscovery of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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