{"id":5005,"date":"2021-06-29T03:13:51","date_gmt":"2021-06-28T19:13:51","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=5005"},"modified":"2021-06-29T03:13:51","modified_gmt":"2021-06-28T19:13:51","slug":"the-important-role-of-c8h13n3o","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=5005","title":{"rendered":"The important role of C8H13N3O"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1190380-49-4, category: pyrazoles-derivatives<\/a><\/p>\n

Into a 100-mL round-bottom flask was placed compound 14.2 (85 mg, 0.24 mmol, 1.00 eq.), n-BuOH (15 mL), 1-(oxan-4-yl)-1H-pyrazol-4-amine (61 mg, 0.36 mmol, 1.50 eq.), and hydrogen chloride in dioxane (1 mL, 4N). The resulting solution was stirred for 30 h at 110 C in an oil bath and then concentrated in vacuo. The resulting solution was diluted with H20. The pH value of the solution was adjusted to 10 with sodium carbonate and the solids were collected by filtration. The solid was dried under infrared light. This resulted in 71.4 mg (61%) of I-22 as an off-white solid. LC-MS (ESI, m\/z): [M+H+]= 481.2; 1H NMR: (4d-MeOD, ppm): 7.881 (1H, s), 7.594 (1H, s), 7.055-7.065QH, m), 6.053-6.063 (1H, m), 4.310-4.411(1H, m), 4.048-4.310 (3H, m), 3.974 (3H, s), 3.623-3.743 (4H, m), 3.537-3.623 (2H, m), 2.634-2.644 (4H, m), 2.275-2.409 (3H, m), 2.019-2.167 (6H, m), 1.335-1.563 (4H, m).<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine C.; BOYCE, Sarah; (135 pag.)WO2017\/4133; (2017); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[210,131],"tags":[126],"class_list":["post-5005","post","type-post","status-publish","format-standard","hentry","category-1190380-49-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 1190380-49-4, name is 1-(Tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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