{"id":4987,"date":"2021-06-28T03:46:57","date_gmt":"2021-06-27T19:46:57","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4987"},"modified":"2021-06-28T03:46:57","modified_gmt":"2021-06-27T19:46:57","slug":"brief-introduction-of-39806-90-1-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4987","title":{"rendered":"Brief introduction of 39806-90-1"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/39806-90-1.html\">Related Products of 39806-90-1<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n<p>To a solution of 4-iodo-l-methyl-lH-pyrazole (23.31 mg, 0.112 mmol) in anhydrous DMSO (5 ml) was added intermediate 19.6-2 (20 mg, 0.075 mmol), (Irans)-N 1.N2-dimethylcycloheane- 1, 2-diamine (2.125 mg, 0.015 mmol), potassium phosphate (47.6 mg, 0.224 mmol), and Cul (1.423 mg, 7.47 pmol). The resulting mixture was stirred at 90C under N2 protection for 12 hours. Afterward, the crude reaction solution was filtered and concentrated. The crude material was purified by pre-HPLC (TFA) to give example 19.7-2, ( R,R or 5riV)-5-chloro-6-(3-nuoro- 1 &#8211; methylpiperidin-4-yl)-l-(l-methyl-lH-pyrazol-4-yl)-lH-indazole, TFA salt. MS (ESI) m\/z calc?d for Ci7H20ClFN5 [M+H]+ 348, found 348. NMR (400 MHz, CD3OD) d 8.12-8.22 (m, 2H), 7.94 (s, 1H), 7.87 (s, 1H), 7.66 (s, 1H), 5.22-5.48 (m, 1H), 3.75-4.03 (m, 5H), 3.60 (m, 1H), 3.15-3.31 (m, 1H), 3.15-3.31 (m, 1H), 3.03 (s, 3H), 2.26 (br s, 1H), 2.10 (m, 1H). LRRK2 IC50 3.0 nM.<\/p>\n<p>The synthetic route of 4-Iodo-1-methyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2020092136&#038;F=0\">Patent; MERCK SHARP &amp; DOHME CORP.; SIMOV, Vladimir; KAPLAN, William, P.; ACTON, John, J., III; ARDOLINO, Michael, J.; CHEN, Joanna, L.; FULLER, Peter, H.; GUNAYDIN, Hakan; LI, Derun; LIU, Ping; LOGAN, Kaitlyn Marie; METHOT, Joey; MORRIELLO, Gregori, J.; NEELAMKAVIL, Santhosh, F.; TORRES, Luis; YAN, Xin; ZHOU, Hua; (0 pag.)WO2020\/92136; (2020); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The synthetic route of 4-Iodo-1-methyl-1H-pyrazole has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[162,131],"tags":[127],"class_list":["post-4987","post","type-post","status-publish","format-standard","hentry","category-39806-90-1","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Brief introduction of<\/title>\n<meta name=\"description\" content=\"Related Products of 39806-90-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4987\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Brief introduction of\" \/>\n<meta property=\"og:description\" content=\"Related Products of 39806-90-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4987\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-27T19:46:57+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4987\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4987\",\"name\":\"Brief introduction of\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-06-27T19:46:57+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 39806-90-1, In the next few decades, the world population will flourish. 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