{"id":4965,"date":"2021-06-25T03:30:36","date_gmt":"2021-06-24T19:30:36","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4965"},"modified":"2021-06-25T03:30:36","modified_gmt":"2021-06-24T19:30:36","slug":"a-new-synthetic-route-of-c4h6n2o","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4965","title":{"rendered":"A new synthetic route of C4H6N2O"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25222-43-9, Safety of (1H-Pyrazol-4-yl)methanol<\/a><\/p>\n

Step 1: 4-(tert-Butyl-dimethyl-silanyloxymethyl)-1H-pyrazole (1H-Pyrazol-4-yl)-methanol (368 mg, [CAS Reg. No. 25222-43-9]) was dissolved in DMF (15 mL) and cooled to 0\u00b0 C. To this solution was added triethylamine (455 mg), 4-dimethylaminopyridine (46 mg) and tert-butyldimethylchlorsilane (678 mg). Stirring was continued for 2 hours at r.t. The reaction mixture was poured into ice and extracted with chloroform. The combined organic layers were washed with brine, dried over Na2SO4, filtered and the solvent was evaporated. The residue was purified by flash chromatography (silica gel, heptane:ethyl acetate=100:0 to 0:100, then ethylacetate_methanol=95:5) to give the title compound as a yellow oil (348 mg, 42percent). MS (m\/e)=213.3 [MH+].<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1H-Pyrazol-4-yl)methanol, and friends who are interested can also refer to it.<\/p>\n

Reference:
Patent; Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius; US2010\/249139; (2010); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (1H-Pyrazol-4-yl)methanol, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[146,131],"tags":[145],"class_list":["post-4965","post","type-post","status-publish","format-standard","hentry","category-25222-43-9","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nA new synthetic route of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25222-43-9, Safety of (1H-Pyrazol-4-yl)methanol\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4965\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of\" \/>\n<meta property=\"og:description\" content=\"Adding a certain compound to certain chemical reactions, such as: 25222-43-9, name is (1H-Pyrazol-4-yl)methanol, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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