{"id":4957,"date":"2021-06-25T03:29:46","date_gmt":"2021-06-24T19:29:46","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4957"},"modified":"2021-06-25T03:29:46","modified_gmt":"2021-06-24T19:29:46","slug":"introduction-of-a-new-synthetic-route-about-3-methylpyrazole","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4957","title":{"rendered":"Introduction of a new synthetic route about 3-Methylpyrazole"},"content":{"rendered":"

Related Products of 1453-58-3<\/a>, These common heterocyclic compound, 1453-58-3, name is 3-Methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

3-Methyl-1H-pyrazole (1 g, 12.18 mmol), phenylboronic acid (3 g, 24.36 mmol) and pyridine (2 mL, 24.36 mmol) were dissolved (160 mL) and Cu(AcO)2 (3.32 g, 18.27 mmol) and molecular sieves were added and mixture was stirred at r.t. for 48 h. Suspension was filtered through Celite and concentrated and the crude thus obtained was purified by normal phase chromatography using hexane\/ethyl acetate from 0% to 7.5% to yield the title compound (83% yield). LRMS: m\/z 159 (M+1)+ Retention time: 2.83 min (Method B) 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 2.38 (s, 3 H) 6.25 (d, J=2.34 Hz, 1 H) 7.18-7.32 (m, 1 H) 7.42 (t, 2 H) 7.65 (dd, J=8.60, 1.17 Hz, 2 H) 7.81 (d, J=2.34 Hz, 1 H).<\/p>\n

Statistics shows that 3-Methylpyrazole is playing an increasingly important role. we look forward to future research findings about 1453-58-3.<\/p>\n

Reference:
Patent; Almirall, S.A.; Erra Sola, Montserrat; Aguilar Izquierdo, Nuria; Carrascal Riera, Marta; Taboada Martinez, Lorena; Navarro Romero, Eloisa; Vidal Juan, Bernat; EP2390252; (2011); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 3-Methylpyrazole is playing an increasingly important role. we look forward to future research findings about 1453-58-3.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[175,131],"tags":[145],"class_list":["post-4957","post","type-post","status-publish","format-standard","hentry","category-1453-58-3","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"Related Products of 1453-58-3, These common heterocyclic compound, 1453-58-3, name is 3-Methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=4957\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Introduction of a new synthetic route about\" \/>\n<meta property=\"og:description\" content=\"Related Products of 1453-58-3, These common heterocyclic compound, 1453-58-3, name is 3-Methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=4957\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-24T19:29:46+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=4957\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=4957\",\"name\":\"Introduction of a new synthetic route about\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-06-24T19:29:46+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 1453-58-3, These common heterocyclic compound, 1453-58-3, name is 3-Methylpyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=4957#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=4957\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=4957#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Introduction of a new synthetic route about 3-Methylpyrazole\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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