{"id":4955,"date":"2021-06-25T03:29:46","date_gmt":"2021-06-24T19:29:46","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4955"},"modified":"2021-06-25T03:29:46","modified_gmt":"2021-06-24T19:29:46","slug":"new-learning-discoveries-about-92525-10-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4955","title":{"rendered":"New learning discoveries about 92525-10-5"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/92525-10-5.html\">Electric Literature of 92525-10-5<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 92525-10-5 name is 3-Iodo-1-methyl-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n<p>A suspension of 3 ,3-dimethyl-6- (4,4,5 ,5-tetramethyl- 1,3 ,2-dioxaborolan-2-yl)indolin-2-one (200 mg) and 5-bromo-2-methylpyrimidine (181 mg) in 1,4-dioxane (2 ml) and aqueous sodiumcarbonate (2 M) was flushed with argon, then [1,1?-bis(diphenylphosphino)ferrocene] dichloropalladium(II) (26 mg) was added and stirring was continued at 115 C for 3 h. The mixture was evaporated and the residue purified by flash chromatography (silica gel, gradient, 0% to 10% MeOH in dichloromethane) to give the title compound (148 mg, 84%) as a brown solid. MS (mlz): 254.2 [(M+H) :_The title compound was prepared in analogy to example ic using 3,3-dimethyl-6-(4,4,5,5- tetramethyl- 1,3 ,2-dioxaborolan-2-yl)indolin-2-one from example lb and 3-iodo- i-methyl-i Hpyrazole to give the title compound (26%) as an off-white solid. MS (mlz): 242.1 [(M+H)?i.<\/p>\n<p>At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Iodo-1-methyl-1H-pyrazole, and friends who are interested can also refer to it.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2015197567&#038;F=0\">Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HILPERT, Hans; KOLCZEWSKI, Sabine; HUMM, Roland; STOLL, Theodor; MUSER, Thorsten; PLANCHER, Jean-Marc; GAUFRETEAU, Delphine; (142 pag.)WO2015\/197567; (2015); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Iodo-1-methyl-1H-pyrazole, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[172,131],"tags":[127],"class_list":["post-4955","post","type-post","status-publish","format-standard","hentry","category-92525-10-5","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New learning discoveries about<\/title>\n<meta name=\"description\" content=\"Electric Literature of 92525-10-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 92525-10-5 name is 3-Iodo-1-methyl-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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The downstream synthesis method of this compound is introduced below.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.pyrazoles-derivatives.com\/?p=4955","og_locale":"en_US","og_type":"article","og_title":"New learning discoveries about","og_description":"Electric Literature of 92525-10-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 92525-10-5 name is 3-Iodo-1-methyl-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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