{"id":4925,"date":"2021-06-24T04:24:34","date_gmt":"2021-06-23T20:24:34","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4925"},"modified":"2021-06-24T04:24:34","modified_gmt":"2021-06-23T20:24:34","slug":"extracurricular-laboratory-synthetic-route-of-31230-17-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4925","title":{"rendered":"Extracurricular laboratory: Synthetic route of 31230-17-8"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 31230-17-8<\/a><\/p>\n

4.1.1 N-(3-methyl-1H-pyrazol-5-yl)acetamide (2) 5-methyl-1H-pyrazol-3-amine (1) (10g, 103?mmol) was dissolved in 100?mL of distilled water, NaHCO3 (26g, 309?mmol) was slowly added. Acetic anhydride (19.5?mL, 206?mmol) was then added dropwise and the resulting suspension was heated at reflux for 16?h (monitored by TLC). Then, the mixture was allowed to cool down to RT, white crystals precipitated slowly. The precipitate was collected, washed with water and dried to provide the desired product 2 (6.2g, 44?mmol, 43% yield) without further purification. Mp: 210-211?C; 1H NMR (400?MHz, DMSO-d6) delta 11.92 (s, 1H), 10.19 (s, 1H), 6.24 (s, 1H), 2.17 (s, 3H), 1.96 (s, 3H).<\/p>\n

According to the analysis of related databases, 31230-17-8, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Article; Zhang, Qiumeng; Shen, Qianqian; Gao, Lixin; Tong, Linjiang; Li, Jia; Chen, Yi; Lu, Wei; European Journal of Medicinal Chemistry; vol. 158; (2018); p. 428 – 441;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 31230-17-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[207,131],"tags":[145],"class_list":["post-4925","post","type-post","status-publish","format-standard","hentry","category-31230-17-8","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nExtracurricular laboratory: Synthetic route of<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31230-17-8, name is 5-Methyl-1H-pyrazol-3-amine, This compound has unique chemical properties. 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