{"id":4924,"date":"2021-06-24T04:24:34","date_gmt":"2021-06-23T20:24:34","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4924"},"modified":"2021-06-24T04:24:34","modified_gmt":"2021-06-23T20:24:34","slug":"analyzing-the-synthesis-route-of-c4h4brn3o2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4924","title":{"rendered":"Analyzing the synthesis route of C4H4BrN3O2"},"content":{"rendered":"

Synthetic Route of 89607-15-8<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89607-15-8, name is 3-Bromo-1-methyl-4-nitro-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

Step 4: Into a 25 mL round bottom flask containing a solution of 3-bromo-1-methyl-4-nitro-1H- pyrazole (1.0 g, 5 mmol) in toluene (5 mL) were added tributyl(vinyl)tin (1.7 mL, 58 mmol) andtetrakis(triphenylphosphine)palladium(0) (300 mg, 0.25 mmol) and the reaction was heated at120 C for 6 h. The reaction mixture was cooled to room temperature, concentrated and purifiedby flash chromatography eluting with ethyl acetate in petroleum ether (15-20%) to afford 1-methyl-4-nitro-3-vinyl-1H-pyrazole as a solid. ?H NMR (CDC13, 300 MHz): 8.07 (s, 1H), 7.22(dd,J= 17.6, 11.2 Hz, 1H), 6.19 (dd,J= 17.7, 4.6 Hz, 1H), 5.54(dd,J= 11.1, 1.6 Hz, 1H), 3.97(s, 3H).<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 3-Bromo-1-methyl-4-nitro-1H-pyrazole. I believe this compound will play a more active role in future production and life.<\/p>\n

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIM, Jongwon; ALTMAN, Michael, D.; BRUBAKER, Jason, D.; GIBEAU, Craig, R.; (187 pag.)WO2016\/144846; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 3-Bromo-1-methyl-4-nitro-1H-pyrazole. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[359,131],"tags":[127],"class_list":["post-4924","post","type-post","status-publish","format-standard","hentry","category-89607-15-8","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nAnalyzing the synthesis route of<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 89607-15-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 89607-15-8, name is 3-Bromo-1-methyl-4-nitro-1H-pyrazole, This compound has unique chemical properties. 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