{"id":4903,"date":"2021-06-23T03:17:40","date_gmt":"2021-06-22T19:17:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4903"},"modified":"2021-06-23T03:17:40","modified_gmt":"2021-06-22T19:17:40","slug":"simple-exploration-of-25016-09-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4903","title":{"rendered":"Simple exploration of 25016-09-5"},"content":{"rendered":"

Synthetic Route of 25016-09-5<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25016-09-5 name is 1,3-Dimethyl-1H-pyrazole-5-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

1 Preparation of 2-pyridyl-(1,3-dimethyl-5-pyrazolyl)methanol: 300 ml of dry tetrahydrofuran solution containing 5.5 g of 2-bromopyridine was cooled to -78C, and 5.45 g of n-butyl lithium hexane solution (15 w\/w %) was dropwise added thereto and stirred for 30 minutes. Then, 4.2 g of 1,3-dimethyl-5-formylpyrazole was dropwise added thereto. Afterwards, this was gradually heated up to room temperature and stirred for 15 hours. The solution was neutralized by adding 2 N hydrochloric acid thereto, and then extracted three times each with 150 ml of ethyl acetate. The organic layer was dried with anhydrous sodium sulfate, the solvent was removed by distillation under reduced pressure, and the residue was purified by silica gel column chromatography (developing solution; chloroform) to give 5.2 g of 2-pyridyl-(1,3-dimethyl-5-pyrazolyl)methanol as a brown oily product.<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Dimethyl-1H-pyrazole-5-carbaldehyde, and friends who are interested can also refer to it.<\/p>\n

Reference:
Patent; NISSAN CHEMICAL INDUSTRIES, LIMITED; EP556396; (1993); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3-Dimethyl-1H-pyrazole-5-carbaldehyde, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[333,131],"tags":[126],"class_list":["post-4903","post","type-post","status-publish","format-standard","hentry","category-25016-09-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 25016-09-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25016-09-5 name is 1,3-Dimethyl-1H-pyrazole-5-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Simple exploration of","description":"Synthetic Route of 25016-09-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25016-09-5 name is 1,3-Dimethyl-1H-pyrazole-5-carbaldehyde, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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