{"id":4900,"date":"2021-06-23T03:17:40","date_gmt":"2021-06-22T19:17:40","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4900"},"modified":"2021-06-23T03:17:40","modified_gmt":"2021-06-22T19:17:40","slug":"application-of-c7h11n3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4900","title":{"rendered":"Application of C7H11N3"},"content":{"rendered":"

118430-74-3, name is 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine<\/a><\/p>\n

N-(4-chloro-6-methoxy-2-methyl-9H-pyrimido [4,5-bj indol-7-yl)acetamide (384 mg, 1.26 mmol), 3 -cyclopropyl- 1-methyl-i H-pyrazol-5-amine (520 mg, 3.79 mmol), and potassium tert-butoxide (709 mg, 6.32 mmol) were dissolved in DMSO (18 mL) and the reaction was heated to 140C. After overnight the reaction was cooled to room temperature, quenched with saturated ammonium chloride, and extracted with ethyl acetate. The ethyl acetate layers was washed with brine, dried over sodium sulfate, concentrated under reduce pressure and purified by reverse phase preparative HPLC to give the product (58 mg).<\/p>\n

The synthetic route of 118430-74-3 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WANG, Shaomeng; ZHAO, Yujun; ZHOU, Bing; AGUILAR, Angelo; (114 pag.)WO2016\/138332; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 118430-74-3 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[233,131],"tags":[126],"class_list":["post-4900","post","type-post","status-publish","format-standard","hentry","category-118430-74-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nApplication of<\/title>\n<meta name=\"description\" content=\"118430-74-3, name is 3-Cyclopropyl-1-methyl-1H-pyrazol-5-amine, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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