{"id":4890,"date":"2021-06-23T03:16:53","date_gmt":"2021-06-22T19:16:53","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4890"},"modified":"2021-06-23T03:16:53","modified_gmt":"2021-06-22T19:16:53","slug":"application-of-2-4-nitro-1h-pyrazol-1-ylethanol","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4890","title":{"rendered":"Application of 2-(4-Nitro-1H-pyrazol-1-yl)ethanol"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 42027-81-6 as follows. Recommanded Product: 2-(4-Nitro-1H-pyrazol-1-yl)ethanol<\/a><\/p>\n

Into a 100 mL round-bottom flask purged and maintained under inert atmosphere of nitrogen, were placed compound 33.1 (500 mg, 3.18 mmol, 1.00 equiv) in 10 mL of distilled DMF. This was followed by the addition of sodium hydride (191 mg, 7.96 mmol, 1.50 equiv) in portions. After stirring for 30 mm, Mel (2.26 g, 15.92 mmol, 5.00 equiv) was added dropwise via syringe and the resulting solution was stirred for 16 h at room temperature. The reaction was then quenched with 50 mL of water, extracted with 3 x 60 mL of ethyl acetate. The organic layers were combined and washed with brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified using flash column chromatography to furnish 420 mg (77%) of intermediate 33.2 as a yellow solid.<\/p>\n

According to the analysis of related databases, 42027-81-6, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine; WO2015\/48281; (2015); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 42027-81-6, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[276,131],"tags":[126],"class_list":["post-4890","post","type-post","status-publish","format-standard","hentry","category-42027-81-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nApplication of<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 42027-81-6 as follows. 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