{"id":4888,"date":"2021-06-23T03:16:53","date_gmt":"2021-06-22T19:16:53","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4888"},"modified":"2021-06-23T03:16:53","modified_gmt":"2021-06-22T19:16:53","slug":"extended-knowledge-of-84547-84-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4888","title":{"rendered":"Extended knowledge of 84547-84-2"},"content":{"rendered":"

Electric Literature of 84547-84-2<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 84547-84-2 name is 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n

A mixture of 4-bromo- 1 -methyl – 1 \/\/-pyrazole-5-carboxylic acid (4.80 g, 23.4 mmol, CAS 84547-84-2) in THF (40.00 mL) was added BH3\/THF (93.60 mL, 1 M). The mixture was stirred at 80 C for 12 hours under N2 atmosphere. To the mixture was added EtOAc (200 mL). The mixture was washed with saturated NaHCO, (200 mL x 3). The organic layer was dried over anhydrous Na2S04, filtered and concentrated to give a residue. The residue was purified by column chromatography (petroleum ether : ethyl acetate = 100 : 0 to 100 : 10) to give (4-bromo-l -methyl- li-pyrazol-5-yl)methanol (4.10 g, 92% yield) as a white solid. 1HNMR (400 MHz, DMSO-6): d 7.26 (s, 1H), 4.62 (s, 2H), 3.86 (s, 3H).<\/p>\n

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid, and friends who are interested can also refer to it.<\/p>\n

Reference:
Patent; RELAY THERAPEUTICS, INC.; D.E. SHAW RESEARCH, LLC; TAYLOR, Alexander, M.; LESCARBEAU, Andre; KELLEY, Elizabeth, H.; SHORTSLEEVES, Kelley, C.; WALTERS, W., Patrick; MURCKO, Mark, Andrew; MCLEAN, Thomas, H.; GUNAYDIN, Hakan; GIORDANETTO, Fabrizio; THERRIEN, Eric; (607 pag.)WO2019\/183367; (2019); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[479,131],"tags":[127],"class_list":["post-4888","post","type-post","status-publish","format-standard","hentry","category-84547-84-2","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nExtended knowledge of<\/title>\n<meta name=\"description\" content=\"Electric Literature of 84547-84-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 84547-84-2 name is 4-Bromo-1-methyl-1H-pyrazole-5-carboxylic acid, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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