{"id":4885,"date":"2021-06-23T03:16:53","date_gmt":"2021-06-22T19:16:53","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4885"},"modified":"2021-06-23T03:16:53","modified_gmt":"2021-06-22T19:16:53","slug":"research-on-new-synthetic-routes-about-c6h7brn2o2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4885","title":{"rendered":"Research on new synthetic routes about C6H7BrN2O2"},"content":{"rendered":"

Some common heterocyclic compound, 1222174-92-6, name is Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate, molecular formula is C6H7BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1222174-92-6<\/a><\/p>\n

A solution of intermediate 2a (500 mg), 2-(trifluoromethyl)beneneboronic acid (650 mg), PEPPSI-Ipr (77 mg) and potassium carbonate (939 mg) in dioxane (10 mL) were heated to 120 C. for 18 h. The mixture was chilled, filtered and the volatiles were removed under reduced pressure. The residue was purified by chromatography (Interchim cartridge50SiHP\/12 g, Cy\/EtOAc) to yield the desired compound (55% yield). [0378] LC-MS (Method 2): m\/z [M+H]+=285.2 (MW calc.=284.23); Rt=0.83 min<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1222174-92-6, its application will become more common.<\/p>\n

Reference:
Patent; Gruenenthal GmbH; Nordhoff, Sonja; Wachten, Sebastian; Kless, Achim; Voss, Felix; Ritter, Stefanie; US2014\/194452; (2014); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. 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