{"id":4863,"date":"2021-06-22T03:38:58","date_gmt":"2021-06-21T19:38:58","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4863"},"modified":"2021-06-22T03:38:58","modified_gmt":"2021-06-21T19:38:58","slug":"simple-exploration-of-92933-47-6-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4863","title":{"rendered":"Simple exploration of 92933-47-6"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 92933-47-6, name is 5-Isopropyl-1H-pyrazole-3-carboxylic acid, A new synthetic method of this compound is introduced below., Product Details of 92933-47-6<\/a><\/p>\n

Step5 (3-(6-Chloro-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)-2,5-dihydro-1H-pyrrol-1-yI)(3-isopropyl-1H-pyrazol-5-yI)methanoneTo a stirred solution of 3-isopropyl-IH-pyrazole-5-carboxylic acid (1.1 g, 7.3 mmol) in DMF (20mL) was added DJEA (3.1 g, 24 mmol) and HATU (3.2 g, 8.5 mrnol) and stined at roomtemperature for 10 mm before the addition of 2-chloro-6-(2,5-dihydro- I H-pyrrol-3 -yl)-4-(l – methyl- IH-pyrazol-4-yl)pyridine hydrochloride (1.8 g, 6.1 mmol). The mixture was stirred at room temperature for 2 hrs under a N2 atomsphere. The mixture was diluted with EtOAc (250 mU, washed with H20 (240 mE x 3). The organic phase was dried over anhydrous Na2SO4, filtered andthe filtrate was concentrated and purified by silica gel column chromatography eluting with 0-10% MeOl-I in DCM to give the desired product (1.8 g, 75% yield) as yellow solid. ?H NMR (400 MHz,DMSO-d6) 38.55, 8.50 (2s, IR), 8.22, 8.19 (2s, IH), 7.99, 7.84 (2s, IH), 7.64 (s, IH), 6.91, 6.87 (25, 111), 6.51, 6.50 (2s, 111), 5.06 (m, IH), 4.90 (ni, 111), 4.68 (m, IH), 4.54 (m, lH), 3.93, 3.89 (2s, 3H), 3.01 -2.97 (m, 1H), 1.27- 1.24 (m, 611).<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n

Reference:
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; LAI, Kwong Wah; LIANG, Jun; ZHANG, Birong; LABADIE, Sharada; ORTWINE, Daniel; DRAGOVICH, Peter; KIEFER, James; GEHLING, Victor, S.; HARMANGE, Jean-Christophe; (263 pag.)WO2016\/57924; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[352,131],"tags":[126],"class_list":["post-4863","post","type-post","status-publish","format-standard","hentry","category-92933-47-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/en.cravatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Simple exploration of","description":"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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