{"id":4855,"date":"2021-06-22T03:38:58","date_gmt":"2021-06-21T19:38:58","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4855"},"modified":"2021-06-22T03:38:58","modified_gmt":"2021-06-21T19:38:58","slug":"brief-introduction-of-1227611-94-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4855","title":{"rendered":"Brief introduction of 1227611-94-0"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1227611-94-0, name is 4-(4-Iodo-1H-pyrazol-1-yl)cyclohexanone, This compound has unique chemical properties. The synthetic route is as follows., Formula: C9H11IN2O<\/a><\/p>\n

Intermediate 21 and 22: cis and trans-4-(4-Iodo-pyrazol-1-yI)-cyclohexanol Sodium borohydride (86 mg; 2.27 mmol; 0.5 eq.) was added portionwise to a suspension of 4-(4-lodo-pyrazol-1-yl)-cyclohexanone (1.33 g; 4.55 mmol; 1.0 eq.) in EtOH (10 mL).The reaction mixture was stirred at RT for 30 mm and concentrated under vacuum. The residue was taken up with EtOAc (50 mL) and washed with NH4CI aq sat (50 mL). The aqueous phase was back-extracted with EtOAc (twice). Combined organic layers were washed with brine, dried over sodium sulfate, filtered and concentrated to give 1.42 g of an oil. Purification by flash chromatography on silica (heptane\/EtOAc, gradient from 80:20 to 40:60) afforded the title compounds.1st eluting compound: colorless glue (234 mg, 18%). Cis-4-(4-Iodo-pyrazol-1-yl)-cyclohexanol. HPLC (Condition A): Rt 2.69 mm (purity 99.7 %). MS (ESI+): 293.1.2nd eluting compound: white powder (730 mg, 55%). Trans-4-(4-lodo-pyrazol-1-yl)-cyclohexanol. HPLC (Condition A): Rt2.65 mm (purity 100 %). MS (ESI+): 293.1.<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1227611-94-0.<\/p>\n

Reference:
Patent; ARES TRADING S.A.; CROSIGNANI, Stefano; JORAND-LEBRUN, Catherine; GERBER, Patrick; MUZERELLE, Mathilde; WO2014\/8992; (2014); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1227611-94-0.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[403,131],"tags":[127],"class_list":["post-4855","post","type-post","status-publish","format-standard","hentry","category-1227611-94-0","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nBrief introduction of<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1227611-94-0, name is 4-(4-Iodo-1H-pyrazol-1-yl)cyclohexanone, This compound has unique chemical properties. 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