{"id":4854,"date":"2021-06-22T03:38:58","date_gmt":"2021-06-21T19:38:58","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4854"},"modified":"2021-06-22T03:38:58","modified_gmt":"2021-06-21T19:38:58","slug":"share-a-compound-c4h5n3o2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4854","title":{"rendered":"Share a compound : C4H5N3O2"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/34334-96-8.html\">Electric Literature of 34334-96-8<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 34334-96-8 as follows.<\/p>\n<p>Add acetonitrile (45 mL) to a mixture of 5-rnethyi-3-nitro-IH-pyrazoie (1.2 g, 9.0 rnmoi). potassium carbonate (2.5 g, 2.0 eq). and (S)-1-chloro-2-propanol (().98 g, 1.2 eq). Stir at 85 C for four days. Cool to a Filter to collect the solid and rinse the solid with EtOAc, then discard the solid. Collect and concentrate the filtrate n vacuo to provide aresidue. Subject the residue to normal phase chromatography, eluting with 50% EtOAc in hexanes. to give the title compound as a white solid (1.1 g, 67%). MS (ES) m\/z 186 (4+H)<\/p>\n<p>According to the analysis of related databases, 34334-96-8, the application of this compound in the production field has become more and more popular.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2018013486&#038;F=0\">Patent; ELI LILLY AND COMPANY; BASTIAN, Jolie Anne; CLAYTON, Joshua Ryan; COATES, David Andrew; SALL, Daniel Jon; WOODS, Timothy Andrew; (58 pag.)WO2018\/13486; (2018); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>According to the analysis of related databases, 34334-96-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[324,131],"tags":[126],"class_list":["post-4854","post","type-post","status-publish","format-standard","hentry","category-34334-96-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Share a compound :<\/title>\n<meta name=\"description\" content=\"Electric Literature of 34334-96-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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