{"id":4853,"date":"2021-06-22T03:38:58","date_gmt":"2021-06-21T19:38:58","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4853"},"modified":"2021-06-22T03:38:58","modified_gmt":"2021-06-21T19:38:58","slug":"the-important-role-of-89088-55-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4853","title":{"rendered":"The important role of 89088-55-1"},"content":{"rendered":"

Synthetic Route of 89088-55-1<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 89088-55-1 as follows.<\/p>\n

The solution of 4-(( 1 -methylpiperidin-4-yl)oxy)-3 -(trifluoromethyl)aniline (77 mg, 437.5 umol) and DIEA (106 mg, 820.3 umol, 143.2 uL) in DCM (3.0 mL) was cooled to – 30C for 0.5 h. Then triphosgene (53 mg, 180.4 umol) was added. The mixture was stirred at -30C for 1 h. Then a solution of 5-bromo-1-methyl-1H-pyrazol-3-amine (150 mg, 546.8 umol) in DCM (1.0 mL) was added. The resulting mixture was stirred at 25C for 1 h. MeOH (2 drop) was added and concentrated to get crude residue. The residue was purified by prep-TLC (Si02, Dichloromethane \/ Methanol = 10\/1) to afford 1-(5-bromo-1-methyl-1H-pyrazol-3-yl)-3-(4-((1- methylpiperidin-4-yl)oxy)-3 -(trifluoromethyl)phenyl)urea (150 mg, crude).<\/p>\n

According to the analysis of related databases, 89088-55-1, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; QUENTIS THERAPEUTICS, INC.; VACCA, Joseph P.; LI, Dansu; BETTIGOLE, Sarah; (143 pag.)WO2018\/222917; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 89088-55-1, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[379,131],"tags":[126],"class_list":["post-4853","post","type-post","status-publish","format-standard","hentry","category-89088-55-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 89088-55-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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