{"id":4845,"date":"2021-06-21T04:01:03","date_gmt":"2021-06-20T20:01:03","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4845"},"modified":"2021-06-21T04:01:03","modified_gmt":"2021-06-20T20:01:03","slug":"a-new-synthetic-route-of-1-methyl-1h-pyrazole-3-carbaldehyde","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4845","title":{"rendered":"A new synthetic route of 1-Methyl-1H-pyrazole-3-carbaldehyde"},"content":{"rendered":"

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27258-32-8, name is 1-Methyl-1H-pyrazole-3-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 27258-32-8<\/a><\/p>\n

To (E)-3-(2-((5-methyl-2 H-tetrazol-2-yl)methyl)-4-(trifluoromethyl) phenyl)- 1 -(piperazin- 1- yl)prop-2-en-1-one (Example 88, step 2) (110 mg, 0.289 mmol) in methanol (2.62 1 mL) was added acetic acid (0.262 m L) and 1-methyl-i H-pyrazole-3-carbaldehyde (commerciallyavailable) (47.8 mg, 0.434 mmol) and the mixture was stirred for 5 minutes. 2-Picoline borane (49.0 mg, 0.463 mmol) was added and the mixture was stirred at room temperature for 18 h. The solvent was removed under reduced pressure. Purification of the crude product by chromatography on silica using a gradient from 0 – 100percent EtOAc in iso-hexane followed by methanol in EtOAc (10percent) afforded the title compound;LC-MS: Rt = 2.i6mins; [M+H] 475.4, Method 8minLowpHvoi.1H NMR (400 MHz, DMSO-d6) O 8.07 (1H, d), 7.85 (1H, 5), 7.80 (1H, d), 7.75 (1H, d), 7.6 (1H, 5), 7.24 (1H, 5), 6.15-6.07 (3H, mult), 3.79 (3H, 5), 3.67-3.50 (4H, mult), 3.48-3.28 (4H, mult), 2.44-2.32 (7H, mult).<\/p>\n

The synthetic route of 27258-32-8 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; NOVARTIS AG; BEATTIE, David; BAETTIG, Urs; LEGRAND, Darren Mark; LISTER, Andrew Stuart; MCKENNA, Jeffrey; PEARCE, David William; SANDHAM, David Andrew; STEWARD, Oliver Ross; THOMSON, Christopher; WO2015\/8230; (2015); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 27258-32-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[417,131],"tags":[126],"class_list":["post-4845","post","type-post","status-publish","format-standard","hentry","category-27258-32-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nA new synthetic route of<\/title>\n<meta name=\"description\" content=\"In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 27258-32-8, name is 1-Methyl-1H-pyrazole-3-carbaldehyde belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. 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