{"id":4836,"date":"2021-06-21T04:00:12","date_gmt":"2021-06-20T20:00:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4836"},"modified":"2021-06-21T04:00:12","modified_gmt":"2021-06-20T20:00:12","slug":"extracurricular-laboratory-synthetic-route-of-36650-74-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4836","title":{"rendered":"Extracurricular laboratory: Synthetic route of 36650-74-5"},"content":{"rendered":"

Electric Literature of 36650-74-5<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36650-74-5, name is 1H-Pyrazole-3-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n

To a solution of ethyl 1 -(6-(2-(4-(3-bromopropoxy)-2-methylphenethyl)-5- fluorophenyl)pyridin-2-yl)-5-(trifl uoromethyl)- 1 H-pyrazole-4-carboxylate (400 mg, 0.630 mmol) and 1H-pyrazole-3-carbonitrile (70.4 mg, 0.757 mmol, Fluorochem Products) in acetonitrile (25 mL) was added cesium carbonate (308 mg, 0.946 mmol). The reactionmixture was stirred at 80 00 for 16 hours. The mixture was concentrated under reduced pressure and EtOAc (50 mL) was added. The mixture was filtered through a celite pad and rinsed with EtOAc (2×25 mL). Combined filtrate was concentrated under reduced pressure to afford crude product which was purified by column chromatography eluting with 12-14% EtOAc in hexane to afford ethyl 1-(6-(2-(4-(3-(3-cyano-1H-pyrazol-1-yl)propoxy)-2-methyl phenethyl)-5-fl uorophenyl) pyridin-2-yl)-5-(trifluoromethyl)- 1 Hpyrazole-4-carboxylate (180 mg, 0.274 mmol, 43.5 % yield) as a gummy product. LCMS_rt=4.28min, m\/z=647.41 [M+H]<\/p>\n

The synthetic route of 1H-Pyrazole-3-carbonitrile has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GOODMAN, Krista B.; KRAUSS, Achim Hans-Peter; LE MONNIER DE GOUVILLE, Anne-Charlotte; DODIC, Nerina; WO2015\/33307; (2015); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 1H-Pyrazole-3-carbonitrile has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[357,131],"tags":[145],"class_list":["post-4836","post","type-post","status-publish","format-standard","hentry","category-36650-74-5","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nExtracurricular laboratory: Synthetic route of<\/title>\n<meta name=\"description\" content=\"Electric Literature of 36650-74-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36650-74-5, name is 1H-Pyrazole-3-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4836\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Extracurricular laboratory: Synthetic route of\" \/>\n<meta property=\"og:description\" content=\"Electric Literature of 36650-74-5, In the next few decades, the world population will flourish. 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