{"id":4818,"date":"2021-06-21T04:00:12","date_gmt":"2021-06-20T20:00:12","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4818"},"modified":"2021-06-21T04:00:12","modified_gmt":"2021-06-20T20:00:12","slug":"introduction-of-a-new-synthetic-route-about-83725-05-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4818","title":{"rendered":"Introduction of a new synthetic route about 83725-05-7"},"content":{"rendered":"

Electric Literature of 83725-05-7<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 83725-05-7 as follows.<\/p>\n

A mixture of N-(5-methyl-1H-pyrazol-3-yl)acetamide (1.448 g, 10.4 mmol),1 3,4-dihydro-2H-pyran (2.39 mL, 26.0 mmol) and trifluoroacetic acid (15 muL, 0.208 mmol) in anhydrous MeCN (15 mL) was refluxed for 2 h. Solvent was evaporated and the residue was resuspended in CH2Cl2 (50 mL) and washed with H2O and brine. After drying with Na2SO4, solvent evaporation and silica gel column chromatography (PE-EtOAc, 6:4) N-(5-Methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)acetamide (1.87 g, quantitative) was obtained. 1Lu, Y.; Kraatz, H.-B. Inorg. Chim. Acta 2004, 357, 159-1661H NMR (400 MHz, CDCl3): =7.61 (bs, 1H), 6.50 (s, 1H), 5.15 (dd, J=10.0 Hz, J=2.4 Hz, 1H), 4.05 (d, J=11.4 Hz, 1H), 3.63 (dt, J=11.8 Hz, J=2.5 Hz, 1H), 2.31 (s, 3H), 2.30 (m, 1H), 2.09 (s, 3H), 2.06 (m, 1H), 1.86 (d, J=11.0 Hz, 1H), 1.63-1.67 (m, 3H).MS (ESI): m\/z=224.37 [MH+].<\/p>\n

According to the analysis of related databases, 83725-05-7, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; AC IMMUNE SA; US2010\/144793; (2010); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 83725-05-7, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[277,131],"tags":[126],"class_list":["post-4818","post","type-post","status-publish","format-standard","hentry","category-83725-05-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"Electric Literature of 83725-05-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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