{"id":4812,"date":"2021-06-18T07:03:37","date_gmt":"2021-06-17T23:03:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4812"},"modified":"2021-06-18T07:03:37","modified_gmt":"2021-06-17T23:03:37","slug":"discovery-of-51105-90-9","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4812","title":{"rendered":"Discovery of  51105-90-9"},"content":{"rendered":"<p>In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 51105-90-9 as follows. <a href=\"https:\/\/www.ambeed.com\/products\/51105-90-9.html\">Formula: C5H6N2O2<\/a><\/p>\n<p>General procedure: Sulfonamide A (e.g.1.29 mmol) was dissolved in acetonitrile (15 mL in case of 1.29 mmol scale) and finely powdered potassium carbonate (3.0 eq) and the corresponding azole(1.5 eq) were added. Stirring was continued at 100 &#8211; 110C until TLC showed consumption of starting material. The solvent was removed under reduced pressure, followed by addition of water and dichloromethane. Afterwards, the phases were separated, the organic phase was dried and it was concentrated in vacuo. The crude was either used without further purification or purified as indicated in the examples.<\/p>\n<p>According to the analysis of related databases, 51105-90-9, the application of this compound in the production field has become more and more popular.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2017191000&#038;F=0\">Patent; BAYER PHARMA AKTIENGESELLSCHAFT; WERNER, Stefan; MESCH, Stefanie; CLEVE, Arwed; BRAeUER, Nico; HERBERT, Simon, Anthony; KOCH, Markus; DAHLLOeF, Henrik; OSMERS, Maren; HARDAKER, Elizabeth; LISHCHYNSKYI, Anton; (673 pag.)WO2017\/191000; (2017); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>According to the analysis of related databases, 51105-90-9, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[385,131],"tags":[126],"class_list":["post-4812","post","type-post","status-publish","format-standard","hentry","category-51105-90-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Discovery of<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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