{"id":4809,"date":"2021-06-18T07:03:37","date_gmt":"2021-06-17T23:03:37","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4809"},"modified":"2021-06-18T07:03:37","modified_gmt":"2021-06-17T23:03:37","slug":"sources-of-common-compounds-25016-16-4-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4809","title":{"rendered":"Sources of common compounds: 25016-16-4"},"content":{"rendered":"

Synthetic Route of 25016-16-4<\/a>, These common heterocyclic compound, 25016-16-4, name is 1-(1H-Pyrazol-4-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

A mixture of 3-bromo-5-fluoropyridine (4.1 g, 9.1 mmol), l -(lH-pyrazol-4- yl)ethanone (5, 1.6 g, 9.1 mmol) and Cs2C03(3.55 g, 10.9 mmol) in 15 mL of DMF was heated at 120 C in a microwave oven for 30 minutes. The reaction was cooled to room temperature and diluted with 150 mL of water and filtered. The solid was collected and dried to provide the desired compound (6, 2 g, 7.5 mmol, 83% yield).<\/p>\n

Statistics shows that 1-(1H-Pyrazol-4-yl)ethanone is playing an increasingly important role. we look forward to future research findings about 25016-16-4.<\/p>\n

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; XU, Ying-Zi; ARTIS, Dean, R.; BOWERS, Simeon; HOM, Roy, K.; SHAM, Hing, L.; YUAN, Shendong; WO2013\/142613; (2013); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Statistics shows that 1-(1H-Pyrazol-4-yl)ethanone is playing an increasingly important role. we look forward to future research findings about 25016-16-4.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[460,131],"tags":[126],"class_list":["post-4809","post","type-post","status-publish","format-standard","hentry","category-25016-16-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds:<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 25016-16-4, These common heterocyclic compound, 25016-16-4, name is 1-(1H-Pyrazol-4-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/www.pyrazoles-derivatives.com\/?p=4809\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sources of common compounds:\" \/>\n<meta property=\"og:description\" content=\"Synthetic Route of 25016-16-4, These common heterocyclic compound, 25016-16-4, name is 1-(1H-Pyrazol-4-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\" \/>\n<meta property=\"og:url\" content=\"http:\/\/www.pyrazoles-derivatives.com\/?p=4809\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-17T23:03:37+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=4809\",\"url\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=4809\",\"name\":\"Sources of common compounds:\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-06-17T23:03:37+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Synthetic Route of 25016-16-4, These common heterocyclic compound, 25016-16-4, name is 1-(1H-Pyrazol-4-yl)ethanone, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.\",\"breadcrumb\":{\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=4809#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/www.pyrazoles-derivatives.com\/?p=4809\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/www.pyrazoles-derivatives.com\/?p=4809#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Sources of common compounds: 25016-16-4\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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