{"id":4801,"date":"2021-06-18T07:02:43","date_gmt":"2021-06-17T23:02:43","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4801"},"modified":"2021-06-18T07:02:43","modified_gmt":"2021-06-17T23:02:43","slug":"introduction-of-a-new-synthetic-route-about-35100-92-6","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4801","title":{"rendered":"Introduction of a new synthetic route about 35100-92-6"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 35100-92-6, name is 1,5-Dimethyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35100-92-6, category: pyrazoles-derivatives<\/a><\/p>\n

To an orange, homogeneous solution of methyl 2-oxo-2H-pyran-3-carboxylate (1.9201 g, 12.46 mmol) in DMF (12.44 ml) under nitrogen at 0 C was added 1,5- dimethyl-1H-pyrazol-3-amine (1.3 822 g, 12.44 mmol).. After 6 h, the cold bath wasremoved, and the reaction was stirred to room temperature for 15 mm EDCI (1-(3-dimethylaminopropyl) ethyl carbodiimide) (3.10 g, 16.17 mmol) and DMAP (0.380 g,3.11 mmol) were added. After stirring overnight, the reaction was diluted with EtOAc(200 mL) and water (50 mL). The layers were separated, and the organic layer waswashed with water (50 mL) and brine (50 mL), dried over Na2SO4, filtered andconcentrated in vacuo to give a residue which was purified by flash chromatographyusing an ISCO 330g column (solid loading) eluting with 10-100% EtOAc\/hex. Appropriate fractions were collected and concentrated in vacuo to give methyl 1-(1,5- dimethyl- 1 H-pyrazol-3 -yl)-2-oxo- 1 ,2-dihydropyridine-3 -carboxylate (0.8397 g, 3.40 mmol, 27.3 % yield) as a light orange solid.<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LIU, Chunjian; LIN, James; MOSLIN, Ryan M.; WEINSTEIN, David S.; TOKARSKI, John S.; WO2015\/89143; (2015); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[136,131],"tags":[126],"class_list":["post-4801","post","type-post","status-publish","format-standard","hentry","category-35100-92-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nIntroduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 35100-92-6, name is 1,5-Dimethyl-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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