{"id":4788,"date":"2021-06-18T07:02:43","date_gmt":"2021-06-17T23:02:43","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4788"},"modified":"2021-06-18T07:02:43","modified_gmt":"2021-06-17T23:02:43","slug":"research-on-new-synthetic-routes-about-c4h6n2s","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4788","title":{"rendered":"Research on new synthetic routes about C4H6N2S"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1393128-21-6, name is 4-(Methylthio)-1H-pyrazole, A new synthetic method of this compound is introduced below., Quality Control of 4-(Methylthio)-1H-pyrazole<\/a><\/p>\n

To a solution of CI (300 mg, 0.679 mmol) in acetone (6 mL) was added K2C03 (280 mg) and 4-(methylthio)- lH-pyrazole (115 mg, 1.01 mmol). The mixture was stirred at 25C for 4 hrs. The solvent was removed by rotary evaporator. To the mixture was added water (6 mL) and EtOAc (8 mL). The organic layer was separated. The aqueous phase was extracted with EtOAc (2 x 8 mL). The combined organic layers was washed with brine (10 mL), dried over Na2S04, filtered and evaporated to give a residue, which was purified by preparative HPLC to afford compound 21 (30.3 mg, 75%). [349] 21: (400 MHz, CDC13) delta 7.53 (s, IH), 7.41 (s, IH), 4.94- 4.87 (m, IH), 4.86-4.78 (m, IH), 3.53 (d, = 9.0 Hz, IH), 3.32 (s, 3H), 3.18 (d, = 9.0 Hz, IH), 2.61-2.52 (m, IH), 2.34 (s, 3H), 2.24-2.13 (m, IH), 2.08-1.99 (m, IH), 1.96-1.86 (m, 2H), 1.79-1.61 (m, 8H), 1.52-1.35 (m, 5H), 1.27 (s, 9H), 0.66 (s, 3H). LCMS Rt = 0.900 min in 1.5 min chromatography, MS ESI calcd. for C27H42N203SNa [M+Na]+ 497, found 497<\/p>\n

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n

Reference:
Patent; SAGE THERAPEUTICS, INC.; ROBICHAUD, Albert, Jean; SALITURO, Francesco, G.; HARRISON, Boyd, L.; MARTINEZ BOTELLA, Gabriel; (157 pag.)WO2016\/134301; (2016); A2;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[708,131],"tags":[126],"class_list":["post-4788","post","type-post","status-publish","format-standard","hentry","category-1393128-21-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nResearch on new synthetic routes about<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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