{"id":4783,"date":"2021-06-17T03:31:51","date_gmt":"2021-06-16T19:31:51","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4783"},"modified":"2021-06-17T03:31:51","modified_gmt":"2021-06-16T19:31:51","slug":"new-downstream-synthetic-route-of-127107-23-7","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4783","title":{"rendered":"New downstream synthetic route of 127107-23-7"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127107-23-7, Safety of 1-Methyl-1H-pyrazol-4-amine hydrochloride<\/a><\/p>\n

2-((6-((2,5-dichloropyrimidin-4-yl)amino)hexahydrofuro[3,2-b]furan-3-yl)oxy)ethanol (0.18 g, 0.54 mmol) was suspended in n-BuOH (5 mL) and 1-methylpyrazol-4-amine hydrochloride (0.15 g, 1.10 mmol) and N,N-diisopropylethylamine (0.28 g, 2.18 mmol) were added thereto. The mixture was placed in a sealed tube and then heated to 150 C with stirring overnight and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (DCM \/ MeOH (v \/ v) = 20\/1). The title compound was obtained as a brown viscous liquid (42 mg, 20%).<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Li Xiaobo; Dai Weilong; Wang Tingjin; (74 pag.)CN104926824; (2017); B;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298,131],"tags":[126],"class_list":["post-4783","post","type-post","status-publish","format-standard","hentry","category-127107-23-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nNew downstream synthetic route of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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