{"id":4775,"date":"2021-06-17T03:31:01","date_gmt":"2021-06-16T19:31:01","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4775"},"modified":"2021-06-17T03:31:01","modified_gmt":"2021-06-16T19:31:01","slug":"introduction-of-a-new-synthetic-route-about-3-1h-pyrazol-1-ylphenylmethanamine","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4775","title":{"rendered":"Introduction of a new synthetic route about (3-(1H-Pyrazol-1-yl)phenyl)methanamine"},"content":{"rendered":"<p>These common heterocyclic compound, 687635-04-7, name is (3-(1H-Pyrazol-1-yl)phenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. <a href=\"https:\/\/www.ambeed.com\/products\/687635-04-7.html\">Safety of (3-(1H-Pyrazol-1-yl)phenyl)methanamine<\/a><\/p>\n<p>To 3-pyrazol-1-yl-benzylamine (0.5 mmol) in THF (2 mL) at room temperature were added Iso-butylaldehyde (0.6 mmol) and anhydrous magnesium sulfate (60 mg). After stirring for 1.5 h at room temperature, sodium borohydride (0.5 mmol) was added and the mixture stirred for a further 2 h. Water (3 ml) was added to the mixture and stirring resumed for 10 min. Additional water was added (1 ml) and the mixture was extracted with CH2Cl2 (10 mL*3). After being dried over anhydrous magnesium sulfate the solvent was removed under reduced pressure to give the crude product. This material was used in subsequent steps without further purification.<\/p>\n<p>The synthetic route of (3-(1H-Pyrazol-1-yl)phenyl)methanamine has been constantly updated, and we look forward to future research findings.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=US2008242661&#038;F=0\">Patent; Dykes, Graeme James; Fletcher, Stephen Robert; Menet, Christel Jeanne Marie; Merayo, Nuria Merayo; Schmitt, Benoit Antoine; US2008\/242661; (2008); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The synthetic route of (3-(1H-Pyrazol-1-yl)phenyl)methanamine has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[376,131],"tags":[126],"class_list":["post-4775","post","type-post","status-publish","format-standard","hentry","category-687635-04-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Introduction of a new synthetic route about<\/title>\n<meta name=\"description\" content=\"These common heterocyclic compound, 687635-04-7, name is (3-(1H-Pyrazol-1-yl)phenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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