{"id":4766,"date":"2021-06-17T03:31:01","date_gmt":"2021-06-16T19:31:01","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4766"},"modified":"2021-06-17T03:31:01","modified_gmt":"2021-06-16T19:31:01","slug":"extracurricular-laboratory-synthetic-route-of-c6h8n2o2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4766","title":{"rendered":"Extracurricular laboratory: Synthetic route of C6H8N2O2"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/5744-59-2.html\">Electric Literature of 5744-59-2<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5744-59-2, name is 1,5-Dimethyl-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n<p>Step (b) N-((ls,4s)-4-(l,5-dimethyl-lH-pyrazole-3-carboxamido)cyclohexyl)-5-fluoro-2- (3-iodophenoxy)nicotinamide <n=\"115\"\/>To a suspension of N-((ls,4s)-4-aminocyclohexyl)-5-fluoro-2-(3-iodophenoxy Nicotinamide hydrochloride (1.5 g, 3.05 mmol) in acetonitrile (100 mL) was added 1,5-dimethyl-lH- pyrazole-3-carboxylic acid (1.069 g, 7.63 mmol) and triethylamine (4.25 mL, 30.50 mmol). 1- Propanephosphonic acid cyclic anhydride, 1.57M solution in THF (T3P) (5.83 mL, 9.15 mmol) was then added and the mixture stirred at RT for 2 h. The mixture was evaporated to dryness and the residue dissolved in DCM (150 mL) and washed with saturated NaHCO3 (aq), brine, dried (MgSO4) and evaporated to give a foam. The product was purified using column chromatography (eluent = neat EtOAc) to give the sub-title compound as a white foam. Yield: 1.04 g1H NMR (400 MHz, CDCl3) delta 8.36 (dd, J= 8.2, 3.1 Hz, IH), 8.07 (d, J= 3.1 Hz, IH), 7.87 (d, J= 6.7 Hz, IH), 7.64 (dt, J= 7.5, 1.5 Hz, IH), 7.55 (t, J= 1.8 Hz, IH), 7.22 &#8211; 7.14 (m, 2H), 6.69 (d, J= 7.7 Hz, IH), 6.53 (s, IH), 4.26 &#8211; 4.17 (m, IH), 4.12 &#8211; 4.03 (m, IH), 3.78 (s, 3H), 2.28 (s, 3H), 1.95 &#8211; 1.73 (m, 6H), 1.67 &#8211; 1.58 (m, 2H) MS: [M+H]+ = 578 (MultiMode+).<\/p>\n<p>The synthetic route of 1,5-Dimethyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2009144494&#038;F=0\">Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009\/144494; (2009); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The synthetic route of 1,5-Dimethyl-1H-pyrazole-3-carboxylic acid has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[206,131],"tags":[126],"class_list":["post-4766","post","type-post","status-publish","format-standard","hentry","category-5744-59-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Extracurricular laboratory: Synthetic route of<\/title>\n<meta name=\"description\" content=\"Electric Literature of 5744-59-2, In the next few decades, the world population will flourish. 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As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5744-59-2, name is 1,5-Dimethyl-1H-pyrazole-3-carboxylic acid belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4766\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-16T19:31:01+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4766\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4766\",\"name\":\"Extracurricular laboratory: Synthetic route of\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-06-16T19:31:01+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Electric Literature of 5744-59-2, In the next few decades, the world population will flourish. 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