{"id":4764,"date":"2021-06-17T03:31:01","date_gmt":"2021-06-16T19:31:01","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4764"},"modified":"2021-06-17T03:31:01","modified_gmt":"2021-06-16T19:31:01","slug":"simple-exploration-of-400877-57-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4764","title":{"rendered":"Simple exploration of 400877-57-8"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 400877-57-8, name is Methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., name: Methyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate<\/a><\/p>\n

A solution of l-methyl-4-nitro-lH-pyrazole-3-carboxylic acid methyl ester (4.8 g, 25.94 mmol) in dry MeOH (100ml) was thoroughly purged with argon, treated with 10% Pd-C (2.7 g, 2.59 mmol), and again purged with argon. Then the reaction mixture was hydrogenated under a balloon pressure of hydrogen at rt for overnight. The reaction mixture was filtered through a bed of celite. The filtrate was concentrated and dried to give the title compound as gray-white solid (3.4 g, 84%), which was used in the next reaction step without further purification.<\/p>\n

The synthetic route of 400877-57-8 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BLEICHER, Konrad; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; GRUBER, Felix; KOERNER, Matthias; KUHN, Bernd; PETERS, Jens-Uwe; RODRIGUEZ SARMIENTO, Rosa Maria; WO2011\/154327; (2011); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 400877-57-8 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[378,131],"tags":[126],"class_list":["post-4764","post","type-post","status-publish","format-standard","hentry","category-400877-57-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSimple exploration of<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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