{"id":4738,"date":"2021-06-16T04:23:46","date_gmt":"2021-06-15T20:23:46","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4738"},"modified":"2021-06-16T04:23:46","modified_gmt":"2021-06-15T20:23:46","slug":"a-new-synthetic-route-of-c5h6n2o-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4738","title":{"rendered":"A new synthetic route of C5H6N2O"},"content":{"rendered":"

Related Products of 20583-33-9<\/a>, The chemical industry reduces the impact on the environment during synthesis 20583-33-9, name is 1-(1H-Pyrazol-3-yl)ethanone, I believe this compound will play a more active role in future production and life.<\/p>\n

Pyrazole viii (20 g, 0.18 mol) is dissolved in dimethylformamide (DMF) (300 mL), and cesium carbonate (70 g, 0.22 mol) is added, followed by tosylate xxvii (45 g, 0.19 mol). The mixture is stirred for 12 hours, then poured into ice cold water and extracted into ethyl acetate. The organic layer is washed with brine, dried over sodium sulfate, and concentrated. The residue is purified by flash column chromatography (10% ethyl acetate in petroleum ether) to give difluoride xxviii (2.56 g, 0.15 mol) in 83% yield.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1H-Pyrazol-3-yl)ethanone, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; CLAVIUS PHARMACEUTICALS, LLC; SAWYER, J. Scott; (132 pag.)WO2020\/41562; (2020); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1H-Pyrazol-3-yl)ethanone, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[363,131],"tags":[126],"class_list":["post-4738","post","type-post","status-publish","format-standard","hentry","category-20583-33-9","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nA new synthetic route of<\/title>\n<meta name=\"description\" content=\"Related Products of 20583-33-9, The chemical industry reduces the impact on the environment during synthesis 20583-33-9, name is 1-(1H-Pyrazol-3-yl)ethanone, I believe this compound will play a more active role in future production and life.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4738\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new synthetic route of\" \/>\n<meta property=\"og:description\" content=\"Related Products of 20583-33-9, The chemical industry reduces the impact on the environment during synthesis 20583-33-9, name is 1-(1H-Pyrazol-3-yl)ethanone, I believe this compound will play a more active role in future production and life.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4738\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-15T20:23:46+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4738\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4738\",\"name\":\"A new synthetic route of\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-06-15T20:23:46+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Related Products of 20583-33-9, The chemical industry reduces the impact on the environment during synthesis 20583-33-9, name is 1-(1H-Pyrazol-3-yl)ethanone, I believe this compound will play a more active role in future production and life.\",\"breadcrumb\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4738#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.pyrazoles-derivatives.com\/?p=4738\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4738#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u9996\u9875\",\"item\":\"https:\/\/www.pyrazoles-derivatives.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A new synthetic route of C5H6N2O\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/\",\"name\":\"pyrazoles-derivatives\",\"description\":\"Several pyrazole derivatives possess important pharmacological activities and they have been proved useful materials in drug research. 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