{"id":4735,"date":"2021-06-16T04:23:46","date_gmt":"2021-06-15T20:23:46","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4735"},"modified":"2021-06-16T04:23:46","modified_gmt":"2021-06-15T20:23:46","slug":"some-tips-on-1-benzyl-1h-pyrazol-4-amine-hydrochloride","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4735","title":{"rendered":"Some tips on 1-Benzyl-1H-pyrazol-4-amine hydrochloride"},"content":{"rendered":"

Synthetic Route of 1264097-17-7<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1264097-17-7 as follows.<\/p>\n

A mixture of l-benzyl-lH-pyrazol-4-amine hydrochloride (510 mg, 2.43 mmol, 1.19 equiv), 2,6-dichloro-9-(2-methylpropyl)-9H-purine (500 mg, 2.04 mmol, 1.00 equiv), i-propanol (5 mL) and DIEA (1.05 g, 8.12 mmol, 3.98 equiv) was stirred for 6 h at 100C in an oil bath. The resulting mixture was concentrated under vacuum to remove the solvents. The residue was purified on a silica gel column with dichloromethane\/methanol (100\/1) to afford 600 mg (crude) of N-(l-benzyl-lH-pyrazol-4-yl)-2-chloro-9-(2-methylpropyl)-9H-purin-6-amine as a dark red solid.<\/p>\n

According to the analysis of related databases, 1264097-17-7, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BURCH, Jason; ORTWINE, Daniel; PEI, Zhonghua; (118 pag.)WO2016\/91916; (2016); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 1264097-17-7, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[315,131],"tags":[127],"class_list":["post-4735","post","type-post","status-publish","format-standard","hentry","category-1264097-17-7","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nSome tips on<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 1264097-17-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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