{"id":4713,"date":"2021-06-15T04:35:52","date_gmt":"2021-06-14T20:35:52","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4713"},"modified":"2021-06-15T04:35:52","modified_gmt":"2021-06-14T20:35:52","slug":"sources-of-common-compounds-31108-57-3-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4713","title":{"rendered":"Sources of common compounds: 31108-57-3"},"content":{"rendered":"

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31108-57-3 as follows. Formula: C4H3N3<\/a><\/p>\n

EXAMPLE P7: Preparation of 1-[6-[3-chloro-6-(trifluoromethvnpyrazolo[4,3-clpyridin-2-yll-5- ethylsulfonyl-2-pyridyllpyrazole-4-carbonitrile (compound P10): (0692) (0693) To a solution of 3-chloro-2-(6-chloro-3-ethylsulfonyl-2-pyridyl)-6-(trifluoromethyl)pyrazolo[4,3-c]pyridine (425 mg, 1 mmol) in N,N-dimethylformamide (4 mL) was added dipotassium carbonic acid (140 mg, 1 mmol), followed by 1 H-pyrazole-4-carbonitrile (93mg, 1 mmol). The mixture was stirred at room temperature for 3hrs. The reaction was diluted with ice water (20 ml), extracted with ethyl acetate (2×40 ml), the combined organic layers washed with water and brine, dried over sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by combiflash (silica gel, 40% EA-cyclohexane) to afford 1-[6-[3-chloro-6-(trifluoromethyl)pyrazolo[4,3-c]pyridin-2-yl]- 5-ethylsulfonyl-2-pyridyl]pyrazole-4-carbonitrile (compound P10) as a solid, mp 251-253C. LCMS (method 3): 482\/484 (M+H)+, retention time 1.50 min.<\/p>\n

According to the analysis of related databases, 31108-57-3, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; MUEHLEBACH, Michel; JUNG, Pierre, Joseph, Marcel; EDMUNDS, Andrew; SIKERVAR, Vikas; RAWAL, Girish; SEN, Indira; HALL, Roger, Graham; (117 pag.)WO2017\/134066; (2017); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 31108-57-3, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[326,131],"tags":[145],"class_list":["post-4713","post","type-post","status-publish","format-standard","hentry","category-31108-57-3","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nSources of common compounds:<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 31108-57-3 as follows. 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