{"id":4708,"date":"2021-06-15T04:35:52","date_gmt":"2021-06-14T20:35:52","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4708"},"modified":"2021-06-15T04:35:52","modified_gmt":"2021-06-14T20:35:52","slug":"some-tips-on-113402-89-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4708","title":{"rendered":"Some tips on 113402-89-4"},"content":{"rendered":"

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 113402-89-4, name is 3-Methyl-1H-pyrazol-5-amine, A new synthetic method of this compound is introduced below., HPLC of Formula: C4H7N3<\/a><\/p>\n

4-Bromo-6,7-dimethoxycinnoline (530 mg, 2.0 mmol), 5-methyl-4H-pyrazol-3-amine (150 mg, 1.5 mmol), toluene (4 mL), tris(dibenzylideneacetone)dipalladium(0) (45 mg, 0.049 mmol), 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthane (70.0 mg, 0.121 mmol) and sodium tert-butoxide (1.80E2 mg, 1.87 mmol) were combined in a 10 mL sealed tube. The reaction was irradiated in a microwave on 300 watts, at 140\u00b0C for 600 seconds The reaction mixture was then filtered through Celite using methanol and methylene chloride and subsequently concentrated. The crude product was then dissolved in 1 mL methanol and filtered through a Gelman Acrodisk 0.45 micron HPLC filter. Purification using a C18 column preparative (30 x 00 mm) HPLC column and a gradient of 20-80percent acetonitrile:water (with 0.1percent formic acid) and a flow rate of 45 mL\/min afforded 40.9mg (8percent) of 6,7-dimethoxy-N-(5-methyl-4H-pyrazol-3-yl)cinnolin-4-amine hydroformate as a yellow solid. MS [M+H] = 286.1, LC\/MS (EI) tR 3.14 min (Method B), .H NMR (DMS0-d6) 8 (ppm) d 12.57 (s, 1 H), 9.38 (s, 1 H), 7.94 (s, 1 H), 6.12 (s, 1.5 H), 5.75 (s, 0.5 H), 4.01 (s, 3 H), 4.00 (s, 3 H), 2.30 (s, 3 H)<\/p>\n

The synthetic route of 113402-89-4 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; MEMORY PHARMACEUTICALS CORPORATION; WO2006\/28957; (2006); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 113402-89-4 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[597,131],"tags":[145],"class_list":["post-4708","post","type-post","status-publish","format-standard","hentry","category-113402-89-4","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nSome tips on<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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Pyrazole derivatives play an important role in antitumor agents.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.pyrazoles-derivatives.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\",\"name\":\"Jessica.F\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/weavatar.com\/avatar\/2d1cec2a99eeaad5a5b217c9cdbfb610?s=96&d=mm&r=g\",\"caption\":\"Jessica.F\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Some tips on","description":"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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