{"id":4691,"date":"2021-06-11T03:41:58","date_gmt":"2021-06-10T19:41:58","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4691"},"modified":"2021-06-11T03:41:58","modified_gmt":"2021-06-10T19:41:58","slug":"continuously-updated-synthesis-method-about-930-36-9-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4691","title":{"rendered":"Continuously updated synthesis method about 930-36-9"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 930-36-9, name is 1-Methylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 930-36-9, Product Details of 930-36-9<\/a><\/p>\n

Preparation 17-1) To a stirred mixture of bromine (50.2 ml) in dichloromethane (14) and anhydrous sodium carbonate (206.8 g) was added a solution of N-methylpyrazole (80 g) in dichloromethane (100 ml) at 0~5 C. After stirring for 1 hour at the same temperature, the mixture was stirred for a further one hour at room temperature and then ice cooled. To the reaction mixture, water (1 l) was added. The dichloromethane layer was separated and the aqueous layer was extracted twice with dichloromethane. The combined organic layer was washed with water and brine, dried over magnesium sulfate and evaporated under reduced pressure. The resulting residue was distilled in vacuo to afford 4-bromo-1-methylpyrazole (150.6 g). bp: 82 C. (20 mmHg) IR (Neat): 3100, 2930 cm-1 NMR (CDCl3, delta): 3.89 (3H, s), 7.38 (1H, s), 7.44 (1H, s) APCI-Mass (m\/z): 161, 163 (MH+)<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methylpyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US5608056; (1997); A;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methylpyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[245,131],"tags":[145],"class_list":["post-4691","post","type-post","status-publish","format-standard","hentry","category-930-36-9","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 930-36-9, name is 1-Methylpyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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