{"id":4686,"date":"2021-06-11T03:41:58","date_gmt":"2021-06-10T19:41:58","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4686"},"modified":"2021-06-11T03:41:58","modified_gmt":"2021-06-10T19:41:58","slug":"continuously-updated-synthesis-method-about-37622-90-5","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4686","title":{"rendered":"Continuously updated synthesis method about 37622-90-5"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 37622-90-5<\/a><\/p>\n

To a solution of 12 4,4,5,5-tetramethyl-2-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1,3,2-dioxaborolane (4) (1.25g, 3.0mmol) and 46 ethyl 1H-pyrazole-4-carboxylate (840mg, 6.0mmol) in 47 pyridine (10mL) was added 48 Cupric acetate, monohydrate (1.19g, 6.0mmol) at room temperature. The mixture was stirred at 50C under a dry atmosphere (CaCl2 tube) overnight. The mixture was quenched with 49 water at room temperature and extracted with EtOAc. The organic layer was separated, washed with 1M HCl and brine, dried over MgSO4 and concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with 0-25% EtOAc in 50 hexane) to give 51 5 (557mg, 43%) as colorless crystals. 1H NMR (300MHz, CDCl3) delta: 1.39 (3H, t, J=7.1Hz), 4.29 (2H, s), 4.36 (2H, q, J=7.1Hz), 7.08-7.11 (1H, m), 7.38-7.57 (6H, m), 7.68 (1H, dd, J=6.6, 2.2Hz), 8.18 (1H, s), 8.50 (1H, s).<\/p>\n

According to the analysis of related databases, 37622-90-5, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Article; Nakahata, Takashi; Tokumaru, Kazuyuki; Ito, Yoshiteru; Ishii, Naoki; Setoh, Masaki; Shimizu, Yuji; Harasawa, Toshiya; Aoyama, Kazunobu; Hamada, Teruki; Kori, Masakuni; Aso, Kazuyoshi; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1598 – 1608;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 37622-90-5, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[218,131],"tags":[126],"class_list":["post-4686","post","type-post","status-publish","format-standard","hentry","category-37622-90-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, This compound has unique chemical properties. 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