{"id":4678,"date":"2021-06-11T03:40:31","date_gmt":"2021-06-10T19:40:31","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4678"},"modified":"2021-06-11T03:40:31","modified_gmt":"2021-06-10T19:40:31","slug":"the-origin-of-a-common-compound-about-5334-43-0","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4678","title":{"rendered":"The origin of a common compound about 5334-43-0"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/5334-43-0.html\">Application of 5334-43-0<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5334-43-0, name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n<p>General procedure: A mixture of 5-amino-1-phenyl-1H-pyrazole-4-carbonitriles (7-12)(0.01 mol) and 20 mL of formic acid was stirred and allowed to reflux for 12 h. The reaction mixture was poured into 50 mL of ice-cold water. The precipitate was collected by filtration and washed with water to produce 13-18 in 68-89% yield. 1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one (13). Yield: 74%.MP:>300 C. IR (cm-1): 3116; 1727; 1660; 1591. 1H NMR (400 MHz,DMSO-d6, TMS, delta in ppm): 8.06-7.39 (m; 5H; HAr); 8.20 (d; 1H;J=3.8 Hz; H6); 8.34 (s; 1H; H3); 12.46 (s; 1H; NH). 13C NMR(100 MHz, DMSO-d6, TMS, delta in ppm): 107.6 (C3a); 121.7 (C2?, C6?);127.1 (C4?); 129.1 (C3?, C5?); 135.9 (C3); 138.2 (C1?); 148.7 (C6); 151.8(C7a); 157.2 (C4). EI [M+1]+ 213.07.<\/p>\n<p>The synthetic route of 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.bioorg.2019.03.037\">Article; Feitosa, Livia M.; da Silva, Edson R.; Hoelz, Lucas V.B.; Souza, Danielle L.; Come, Julio A.A.S.S.; Cardoso-Santos, Camila; Batista, Marcos M.; Soeiro, Maria de Nazare C.; Boechat; Pinheiro, Luiz C.S.; Bioorganic and Medicinal Chemistry; vol. 27; 14; (2019); p. 3061 &#8211; 3069;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The synthetic route of 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[148,131],"tags":[126],"class_list":["post-4678","post","type-post","status-publish","format-standard","hentry","category-5334-43-0","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The origin of a common compound about<\/title>\n<meta name=\"description\" content=\"Application of 5334-43-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5334-43-0, name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4678\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The origin of a common compound about\" \/>\n<meta property=\"og:description\" content=\"Application of 5334-43-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5334-43-0, name is 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4678\" \/>\n<meta property=\"og:site_name\" content=\"pyrazoles-derivatives\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-10T19:40:31+00:00\" \/>\n<meta name=\"author\" content=\"Jessica.F\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jessica.F\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4678\",\"url\":\"https:\/\/www.pyrazoles-derivatives.com\/?p=4678\",\"name\":\"The origin of a common compound about\",\"isPartOf\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#website\"},\"datePublished\":\"2021-06-10T19:40:31+00:00\",\"author\":{\"@id\":\"https:\/\/www.pyrazoles-derivatives.com\/#\/schema\/person\/d9a9f27bed675392c6f363a01ffd49f1\"},\"description\":\"Application of 5334-43-0, In the next few decades, the world population will flourish. 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