{"id":4658,"date":"2021-06-10T03:45:23","date_gmt":"2021-06-09T19:45:23","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4658"},"modified":"2021-06-10T03:45:23","modified_gmt":"2021-06-09T19:45:23","slug":"sources-of-common-compounds-35691-93-1","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4658","title":{"rendered":"Sources of common compounds: 35691-93-1"},"content":{"rendered":"

Some common heterocyclic compound, 35691-93-1, name is Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, molecular formula is C8H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate<\/a><\/p>\n

A microwave vial was charged with ethyl 3,5-dimethyl-1 H-pyrazole-4-carboxylate (1.00 g, 5.95 mmol), methyl vinyl sulfone (0.521 ml, 5.95 mmol), K2CO3 (2.465 g, 17.84 mmol) and DMF (15 ml), and the mixture was irradiated for 30 minutes at 135 C in a personal microwave reactor. The reaction mixture was diluted with EtOAc, washed with brine and dried over magnesium sulfate. The solvent was removed to give ethyl 3,5-dimethyl-1-[2-(methylsulfonyl)ethyl]-1 H-pyrazole-4-carboxylate (1.61 g, 99 % yield). 1 H NMR (400 MHz, CHLOROFORM-d) delta ppm 4.47 (t, J=6.2 Hz, 2 H), 4.30 (q, J=IA Hz, 2 H), 3.65 (t, J=6.2 Hz, 2 H), 2.61 (s, 3 H), 2.60 (s, 3 H), 2.42 (s, 3 H), 1.37 (t, J=IA Hz, 3 H).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 35691-93-1, its application will become more common.<\/p>\n

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008\/157273; (2008); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 35691-93-1, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[217,131],"tags":[126],"class_list":["post-4658","post","type-post","status-publish","format-standard","hentry","category-35691-93-1","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nSources of common compounds:<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 35691-93-1, name is Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, molecular formula is C8H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.pyrazoles-derivatives.com\/?p=4658\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sources of common compounds:\" \/>\n<meta property=\"og:description\" content=\"Some common heterocyclic compound, 35691-93-1, name is Ethyl 3,5-dimethyl-1H-pyrazole-4-carboxylate, molecular formula is C8H12N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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