{"id":4641,"date":"2021-06-10T03:44:31","date_gmt":"2021-06-09T19:44:31","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4641"},"modified":"2021-06-10T03:44:31","modified_gmt":"2021-06-09T19:44:31","slug":"discovery-of-15802-75-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4641","title":{"rendered":"Discovery of 15802-75-2"},"content":{"rendered":"

Related Products of 15802-75-2<\/a>, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15802-75-2, name is 4-Iodo-3-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.<\/p>\n

Under nitrogen protection,To a 10 ml Schlek reaction tube (a glass instrument commonly used in anhydrous oxygenless operation) was added 1.0 mmolBromo-5- (4- (6-bromopyridyl-3) phenyl) pyridine, 2.2 mmol3-methyl-4-iodopyrazole,0.03 mmol of palladium acetate, 0.05 mmol of di-t-butyl (2 ‘, 4′, 6′-triisopropyl-3,6-dimethoxybiphenyl-2-yl) phosphine, 6.0 mmol of sodium tert-butoxide ,And 5 ml of toluene,The reaction tube was purged with nitrogen three times,And then heated to 110 C with an oil bath under magnetic stirring, and the reaction was refluxed for 24 hours. Down to room temperatureThe reaction solution was further added, 4.0 mmol of 4-carboxyphenylboronic acid, 0.03 mmol of palladium acetate,0.06 mmol 2′-dicyclohexylphosphino-2,6-di-I-propyl-4-sulfonate-1,1’-biphenyl sodium,8.0 mmol of potassium carbonate, and 100 mmol of water; and then heated to 100 C with an oil bath under magnetic stirring,The reaction was refluxed for 40 hours. Down to room temperature; add 20 ml of water, filtration, with concentrated hydrochloric acid to adjust the pH of the filtrate to 1,After stirring at room temperature for 3 h, the mixture was filtered, washed with ethanol and dried to obtain product 21, yield 77%.The mass spectrum (ESI) data for this product (C38H28N6O4) was 632.26.<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-3-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; Luoyang Normal College; Li Hongmei; Xu Chen; Wang Zhiqiang; Tu Tianyong; Hao Xinqi; (10 pag.)CN106674208; (2017); A;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Iodo-3-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[513,131],"tags":[127],"class_list":["post-4641","post","type-post","status-publish","format-standard","hentry","category-15802-75-2","category-pyrazoles-derivatives","tag-m-w200-300"],"yoast_head":"\nDiscovery of<\/title>\n<meta name=\"description\" content=\"Related Products of 15802-75-2, In the next few decades, the world population will flourish. 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