{"id":4610,"date":"2021-06-09T03:31:30","date_gmt":"2021-06-08T19:31:30","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4610"},"modified":"2021-06-09T03:31:30","modified_gmt":"2021-06-08T19:31:30","slug":"the-important-role-of-37622-90-5-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4610","title":{"rendered":"The important role of 37622-90-5"},"content":{"rendered":"

37622-90-5, name is Ethyl 4-pyrazolecarboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C6H8N2O2<\/a><\/p>\n

Ethyl 1-(4-(hydroxymethyl)benzyl)-1H-pyrazole-4-carboxylate<\/BOLD> Combined ethyl 1H-pyrazole-4-carboxylate (2.31 g; 16.48 mmol; 1.00 eq.), [4-(chloromethyl)phenyl]methanol (2.58 g; 16.48 mmol; 1.00 eq.), DMAP (0.04 g; 0.33 mmol; 0.02 eq.), and potassium carbonate (4.55 g; 32.97 mmol; 2.00 eq.) in acetonitrile (30.00 ml). Heated the reaction to 90 C. for 2 hours. Let the reaction cool to rt. Diluted reaction with water, extracted with ethyl acetate, combined organics, dried with MgSO4, filtered, and concentrated. The residue was purified by silica gel column to give ethyl 1-(4-(hydroxymethyl)benzyl)-1H-pyrazole-4-carboxylate (3.7 g, 86%)1H NMR (400 MHz, Chloroform-d) delta 7.93 (d, J=0.7 Hz, 1H), 7.84 (d, J=0.7 Hz, 1H), 7.40-7.34 (d, J=6.2 Hz, 2H), 7.24 (d, J=6.2 Hz, 2H), 5.29 (s, 2H), 4.70 (s, 2H), 4.27 (q, J=7.1 Hz, 2H), 1.36-1.29 (m, 3H).<\/p>\n

The synthetic route of 37622-90-5 has been constantly updated, and we look forward to future research findings.<\/p>\n

Reference:
Patent; Global Blood Therapeutics, Inc.; Li, Zhe; Xu, Qing; Yu, Chul; Yee, Calvin; Gwaltney,, II, Stephen L.; Metcalf, Brian W.; Richards, Steven; Lardy, Matthew A.; Setti, Lina; Sham, Hing; US2015\/315198; (2015); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The synthetic route of 37622-90-5 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[218,131],"tags":[126],"class_list":["post-4610","post","type-post","status-publish","format-standard","hentry","category-37622-90-5","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"37622-90-5, name is Ethyl 4-pyrazolecarboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 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