{"id":4588,"date":"2021-06-08T04:12:41","date_gmt":"2021-06-07T20:12:41","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4588"},"modified":"2021-06-08T04:12:41","modified_gmt":"2021-06-07T20:12:41","slug":"some-scientific-research-about-5334-40-7-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4588","title":{"rendered":"Some scientific research about 5334-40-7"},"content":{"rendered":"

Reference of 5334-40-7<\/a>,Some common heterocyclic compound, 5334-40-7, name is 4-Nitro-1H-pyrazole-3-carboxylic acid, molecular formula is C4H3N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.<\/p>\n

To a solution of 4-nitro-1H-pyrazole-3-carboxylic acid (50.0 g, 318 mmol, CAS5334-40-7) in MeOH (250 mL) was added SOCl2 (56.8 g, 477 mmol). The mixture was stirred at 70 C. for 5 hrs. On completion, the mixture was concentrated in vacuo to give the title compound (54.0 g, 99% yield) as white solid. 1H NMR (400 MHz, DMSO-d6) delta 14.40 (s, 1H), 9.98 (s, 1H), 3.89 (s, 3H).<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Nitro-1H-pyrazole-3-carboxylic acid, its application will become more common.<\/p>\n

Reference:
Patent; Kymera Therapeutics, Inc.; Mainolfi, Nello; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (1443 pag.)US2019\/192668; (2019); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. 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