{"id":4573,"date":"2021-06-08T04:12:41","date_gmt":"2021-06-07T20:12:41","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4573"},"modified":"2021-06-08T04:12:41","modified_gmt":"2021-06-07T20:12:41","slug":"new-learning-discoveries-about-c5h7n3o2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4573","title":{"rendered":"New learning discoveries about C5H7N3O2"},"content":{"rendered":"<p>In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 360056-45-7 as follows. <a href=\"https:\/\/www.ambeed.com\/products\/360056-45-7.html\">COA of Formula: C5H7N3O2<\/a><\/p>\n<p>Step 1. Synthesis of 4-(2,6-difluoro-benzoylaminoVlH-pyrazole-3-carboxylic acid ethyl ester; A mixture of 2,6-difluorobenzoic acid (6.32 g, 40.0 mmol), 4-amino-lH-pyrazole- 3-carboxylic acid methyl ester (5.68 g, 40.0 mmol), EDC (8.83 g, 46.1 mmol) and HOBt (6.23 g, 46.1 mmol) in DMF (100 ml) was stirred at ambient temperature overnight. The mixture was reduced in vacuo, the residue taken up in ethyl acetate and then washed with saturated aqueous sodium hydrogen carbonate, water and brine. The organic extracts was dried (MgSO4) and reduced in vacuo to give 4- (2,6-difluoro-benzoylamino)-lH-pyrazole-3-carboxylic acid methyl ester as a yellow solid (9.94 g). (LC\/MS: Rt 2.81, [M+H]+ 282.01).<\/p>\n<p>According to the analysis of related databases, 360056-45-7, the application of this compound in the production field has become more and more popular.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2006070198&#038;F=0\">Patent; ASTEX THERAPEUTICS LIMITED; NOVARTIS AG; WO2008\/7123; (2008); A2;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>According to the analysis of related databases, 360056-45-7, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[265,131],"tags":[126],"class_list":["post-4573","post","type-post","status-publish","format-standard","hentry","category-360056-45-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New learning discoveries about<\/title>\n<meta name=\"description\" content=\"In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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