{"id":4571,"date":"2021-06-08T04:12:41","date_gmt":"2021-06-07T20:12:41","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4571"},"modified":"2021-06-08T04:12:41","modified_gmt":"2021-06-07T20:12:41","slug":"new-downstream-synthetic-route-of-1h-pyrazol-1-ol","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4571","title":{"rendered":"New downstream synthetic route of 1H-Pyrazol-1-ol"},"content":{"rendered":"

Some common heterocyclic compound, 81945-73-5, name is 1H-Pyrazol-1-ol, molecular formula is C3H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1H-Pyrazol-1-ol<\/a><\/p>\n

EXAMPLE 1 part of 1-hydroxypyrazole is mixed thoroughly with 4 parts of potassium carbonate, and the mixture is introduced into an autoclave. Carbon dioxide is forced in at room temperature until the pressure reaches 50 bar, after which heating is carried out for 20 hours at 150 C. The reactor content is then dissolved in water, the solution is acidified with hydrochloric acid, which precipitates the 1-hydroxypyrazole-4-carboxylic acid, and the latter is filtered off and recrystallized from water. 0.68 part (45% of theory) of 1-hydroxypyrazole-4-carboxylic acid of melting point 230 C. is obtained.<\/p>\n

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 81945-73-5, its application will become more common.<\/p>\n

Reference:
Patent; BASF Aktiengesellschaft; US4769473; (1988); A;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 81945-73-5, its application will become more common.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[369,131],"tags":[145],"class_list":["post-4571","post","type-post","status-publish","format-standard","hentry","category-81945-73-5","category-pyrazoles-derivatives","tag-m-w0-100"],"yoast_head":"\nNew downstream synthetic route of<\/title>\n<meta name=\"description\" content=\"Some common heterocyclic compound, 81945-73-5, name is 1H-Pyrazol-1-ol, molecular formula is C3H4N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 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