{"id":4553,"date":"2021-06-08T04:11:32","date_gmt":"2021-06-07T20:11:32","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4553"},"modified":"2021-06-08T04:11:32","modified_gmt":"2021-06-07T20:11:32","slug":"brief-introduction-of-c5h7n3o2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4553","title":{"rendered":"Brief introduction of C5H7N3O2"},"content":{"rendered":"

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 5-Amino-1H-pyrazole-3-acetic acid<\/a><\/p>\n

Example 100[0255] To compound 97 (700mg, 4.96mMol) in 7mL of DMF at O0C was added pyridine (883 muL, 863mg, 10.9ImMoI) followed by careful, dropwise addition of pentafluorophenyl trifluoroacetate (1.68mL, 2.78g, 9.92mMol). Reaction mixture was stirred at 0 C for 10 minutes and 90 minutes at room temperature. 2-chloro-6-methylaniline (1.22mL, 1.4g, 9.92mMol) was added and reaction mixture was stirred overnight at room temperature. Reaction was poured into 5OmL of IN HCl, organic layer was separated. Aqueous layer was extracted with EtOAc. Organic fractions were combined, washed with brine, dried over Na2SO4, filtered and solvent was evaporated to give 1.79g (quant.) of crude product 100 that was used in the next step without purification.<\/p>\n

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 174891-10-2.<\/p>\n

Reference:
Patent; ABRAXIS BIOSCIENCE, LLC; TAO, Chunlin; WANG, Qinwei; NALLAN, Laxman; POLAT, Tulay; KORONIAK, Lukasz; DESAI, Neil; WO2010\/144338; (2010); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 174891-10-2.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[350,131],"tags":[126],"class_list":["post-4553","post","type-post","status-publish","format-standard","hentry","category-174891-10-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nBrief introduction of<\/title>\n<meta name=\"description\" content=\"Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 174891-10-2, name is 5-Amino-1H-pyrazole-3-acetic acid, This compound has unique chemical properties. 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