{"id":4541,"date":"2021-06-07T07:10:13","date_gmt":"2021-06-06T23:10:13","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4541"},"modified":"2021-06-07T07:10:13","modified_gmt":"2021-06-06T23:10:13","slug":"discovery-of-c4h8cln3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4541","title":{"rendered":"Discovery of C4H8ClN3"},"content":{"rendered":"

Synthetic Route of 127107-23-7<\/a>, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows.<\/p>\n

A 25 mL round-bottom flask was charged with intermediate 46.3 (462 mg, 1.17 mmol, 1.00 equiv), n-BuOH (5 mL), 1-methyl-1H-pyrazol-4- amine hydrochloride (187 mg, 1.40 mmol, 1.20 equiv) and HC1 in 1,4-dioxane (0.5 ml). The reaction was stirred for 16 hours at 110 C in an oil bath. The resulting mixture was concentrated under vacuum and diluted with 0.5 mL of sodium carbonate (1 mol\/L). To this mixture was added 1 mL of methanol, and the resulting solution was extracted with 3 x 20 mL of CHC13\/1PA3: 1. The organic layers were combined and dried over anhydrous sodium sulfate and concentrated under vacuum. The crude product was purified using preparative HPLC to furnish 45.7 mg (9%) of compound 1-47 as a white solid. LCMS (ES, m\/z): 457 [M+H], ?H NMR (300 MHz ,CD3OD): oe 7.869 (1H, s), 7.564 (1H, s), 4.8684.597 (1H, s), 4.0454.054 (1H, s), 3.888 (3H, s) 3.736 (4H, t), 2.5592.658 (4H, s), 2.2062.423 (3H, s), 2.0412.103 (2H, m), 1.3111.534 (1OH, m).<\/p>\n

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-4-amine hydrochloride. I believe this compound will play a more active role in future production and life.<\/p>\n

Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine; WO2015\/48281; (2015); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

The chemical industry reduces the impact on the environment during synthesis 1-Methyl-1H-pyrazol-4-amine hydrochloride. I believe this compound will play a more active role in future production and life.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298,131],"tags":[126],"class_list":["post-4541","post","type-post","status-publish","format-standard","hentry","category-127107-23-7","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nDiscovery of<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 127107-23-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, This compound has unique chemical properties. 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