{"id":4535,"date":"2021-06-07T07:09:18","date_gmt":"2021-06-06T23:09:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4535"},"modified":"2021-06-07T07:09:18","modified_gmt":"2021-06-06T23:09:18","slug":"extended-knowledge-of-26621-44-3-3","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4535","title":{"rendered":"Extended knowledge of 26621-44-3"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/26621-44-3.html\">Electric Literature of 26621-44-3<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26621-44-3 name is 3-Nitro-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n<p>To a mixture of 3-nitro-1H-pyrazole (10 g, 88.44 mmol) in DMF (80 mL) was added NaH (4.24 g, 106.13 mmol, 60% purity) in portions at 0 C. Then to the mixture was added SEM-Cl (17.69 g, 106.13 mmol, 18.78 mL) dropwise at 0C. The mixture was stirred at 25 C for 1 h. The resulting mixture was diluted with water and extracted with EtOAc (50 mL\u00d73). The combined organic layers were washed with brine (50 mL\u00d73), dried over Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (SiO2, Petroleum ether\/Ethyl acetate=1:0 to 5:1, Rf = 0.7,0.75) to provide the title compound (29.5 g, crude) as a yellow oil.<\/p>\n<p>At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Nitro-1H-pyrazole, and friends who are interested can also refer to it.<\/p>\n<p>Reference:<br \/><a href=\"http:\/\/v3.espacenet.com\/textdoc?DB=EPODOC&#038;IDX=WO2019120296&#038;F=0\">Patent; KADMON CORPORATION, LLC; LIU, Kevin G.; OLSZEWSKI, Kellen L.; KIM, Ji-In; POYUROVSKY, Masha V.; MORRIS, Koi; YU, Xuemei; LAMARQUE, Christophe; (0 pag.)WO2020\/5935; (2020); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Nitro-1H-pyrazole, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[163,131],"tags":[126],"class_list":["post-4535","post","type-post","status-publish","format-standard","hentry","category-26621-44-3","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Extended knowledge of<\/title>\n<meta name=\"description\" content=\"Electric Literature of 26621-44-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26621-44-3 name is 3-Nitro-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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