{"id":4532,"date":"2021-06-07T07:09:18","date_gmt":"2021-06-06T23:09:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4532"},"modified":"2021-06-07T07:09:18","modified_gmt":"2021-06-06T23:09:18","slug":"discovery-of-16461-94-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4532","title":{"rendered":"Discovery of 16461-94-2"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 16461-94-2, name is 4-Bromo-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16461-94-2, Quality Control of 4-Bromo-1H-pyrazol-3-amine<\/a><\/p>\n

Step 2 :4-(3-Bromopyrazolori,5-a1pyrimidin-6-yl)phenol; A mixture of 3-(dimethylamino)-2-(4-hydroxyphenyl)acrylaldehyde (5.00 g, 0.026 mol), 3-amino-4- bromopyrazole (4.23 g, 0.026 mol), 84 mL of ethanol and 4.2 mL of acetic acid was refluxed for 12 h. The mixture was cooled and the precipitate filtered off, washed twice with water and a small amount of ethanol, then dried in vacuum at 40-500C for 8 h. to give the desired phenol. Yield: 4.66 g (61.5%).<\/p>\n

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n

Reference:
Patent; MERCK SHARP & DOHME LIMITED; MERCK & CO., INC.; WO2007\/85873; (2007); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[188,131],"tags":[126],"class_list":["post-4532","post","type-post","status-publish","format-standard","hentry","category-16461-94-2","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nDiscovery of<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 16461-94-2, name is 4-Bromo-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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