{"id":4527,"date":"2021-06-07T07:09:18","date_gmt":"2021-06-06T23:09:18","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4527"},"modified":"2021-06-07T07:09:18","modified_gmt":"2021-06-06T23:09:18","slug":"continuously-updated-synthesis-method-about-14531-55-6-2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4527","title":{"rendered":"Continuously updated synthesis method about 14531-55-6"},"content":{"rendered":"

Adding a certain compound to certain chemical reactions, such as: 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14531-55-6, Quality Control of 3,5-Dimethyl-4-nitro-1H-pyrazole<\/a><\/p>\n

(0927) Step A (0928) To a solution of 3,5-dimethyl-4-nitro-1H-pyrazole (0.5 g, 3.54 mmol) in acetonitrile (10 mL), K2CO3 (1.4 g, 10.62 mmol) was added and the mixture was stirred at room temperature for 30 minutes. Then 1-bromo-2-fluoroethane (0.67 g, 5.31 mmol) was added dropwise. The mixture was heated at reflux overnight. To the cooled reaction mixture H2O (20 ml) was added. The mixture was extracted with ethyl acetate (3\u00d750 ml), the organic layers were combined, dried over Na2SO4 and evaporated under reduced pressure. The residue was purified on HP-Sil SNAP cartridges using a Biotage Isolera One purification system employing an EtOAc\/n-heptane gradient (5\/95->40\/60) to afford the title compound which was used in the next step without further purification (0.515 g, 77%). (0929) 1H-NMR (400 MHz, DMSO-d6) delta=4.80 (t, 1H), 4.68 (t, 1H), 4.48 (t, 1H), 4.41 (t, 1H), 2.57 (s, 3H), 2.40 (s, 3H).<\/p>\n

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n

Reference:
Patent; AC IMMUNE SA; PIRAMAL IMAGING SA; KROTH, Heiko; NAMPALLY, Sreenivasachary; MOLETTE, Jerome; GABELLIERI, Emanuele; BENDERITTER, Pascal Andre Rene; FROESTL, Wolfgang; SCHIEFERSTEIN, Hanno; MUELLER, Andre; SCHMITT-WILLICH, Heribert; BERNDT, Mathias; (228 pag.)US2017\/2005; (2017); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethyl-4-nitro-1H-pyrazole, other downstream synthetic routes, hurry up and to see.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[236,131],"tags":[126],"class_list":["post-4527","post","type-post","status-publish","format-standard","hentry","category-14531-55-6","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nContinuously updated synthesis method about<\/title>\n<meta name=\"description\" content=\"Adding a certain compound to certain chemical reactions, such as: 14531-55-6, name is 3,5-Dimethyl-4-nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. 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