{"id":4488,"date":"2021-06-04T03:19:45","date_gmt":"2021-06-03T19:19:45","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4488"},"modified":"2021-06-04T03:19:45","modified_gmt":"2021-06-03T19:19:45","slug":"the-important-role-of-478968-48-8","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4488","title":{"rendered":"The important role of 478968-48-8"},"content":{"rendered":"

Synthetic Route of 478968-48-8<\/a>, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 478968-48-8 as follows.<\/p>\n

A mixture of Cul (88 mg, 0.46 mmol, 0.10 equiv), L-proline (108 mg, 0.94 mmol, 0.20 equiv), potassium carbonate (1.3 g, 9.41 mmol, 2.00 equiv), ethyl 3-methoxy-li7-pyrazole-4-carboxylate (800 mg, 4.70 mmol, 1.00 equiv), and 5-bromo-2-(trifluoromethyl)pyrimidine (1.28 g, 5.64 mmol, 1.20 equiv) in DMSO (5 mL) was stirred overnight at 100 C under nitrogen. The reaction mixture was diluted with 40 mL of water, extracted with ethyl acetate, dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified by a silica gel column eluting with ethyl acetate\/petroleum ether (1 :5) to afford the title compound (580mg, 39%) as a white solid.<\/p>\n

According to the analysis of related databases, 478968-48-8, the application of this compound in the production field has become more and more popular.<\/p>\n

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; VERMA, Vishal; SHORE, Daniel; VOLGRAF, Matthew; ESTRADA, Anthony A.; LYSSIKATOS, Joseph; (153 pag.)WO2018\/15410; (2018); A1;<\/a>,
Pyrazole – Wikipedia<\/a>,
Pyrazoles – an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"

According to the analysis of related databases, 478968-48-8, the application of this compound in the production field has become more and more popular.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[527,131],"tags":[126],"class_list":["post-4488","post","type-post","status-publish","format-standard","hentry","category-478968-48-8","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"\nThe important role of<\/title>\n<meta name=\"description\" content=\"Synthetic Route of 478968-48-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. 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