{"id":4481,"date":"2021-06-03T04:03:14","date_gmt":"2021-06-02T20:03:14","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4481"},"modified":"2021-06-03T04:03:14","modified_gmt":"2021-06-02T20:03:14","slug":"extended-knowledge-of-20154-03-4","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4481","title":{"rendered":"Extended knowledge of 20154-03-4"},"content":{"rendered":"<p><a href=\"https:\/\/www.ambeed.com\/products\/20154-03-4.html\">Electric Literature of 20154-03-4<\/a>, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20154-03-4 name is 3-(Trifluoromethyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.<\/p>\n<p>Step 1: Preparation of 4-iodo-3-(truoromethyl)-1H-pyrazole. To a solution of 3- (trifluoromethyl)-1H-pyrazole (500 mg, 3.7 mmol) in 50percent 112S04 at 0 \u00b0C was added MS (992 mg, 4.4 mmol). The suspension was stirred at 0\u00b0C for 10 mm and then at r.t. for 3 hr. The resulting mixture was quenched with water (50 mL), and then stirred overnight. The precipitate was collected by filtration and dried to afford 4-iodo-3-(trifluoromethyl)-1H-pyrazole.LC-MS:m\/z 263 (M+H).<\/p>\n<p>At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(Trifluoromethyl)-1H-pyrazole, and friends who are interested can also refer to it.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.tet.2011.09.029\">Patent; AGIOS PHARMACEUTICALS, INC.; KONTEATIS, Zenon D.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy M.; ZAHLER, Robert; CAI, Zhenwei; ZHOU, Ding; WO2015\/3640; (2015); A1;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-(Trifluoromethyl)-1H-pyrazole, and friends who are interested can also refer to it.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[205,131],"tags":[126],"class_list":["post-4481","post","type-post","status-publish","format-standard","hentry","category-20154-03-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Extended knowledge of<\/title>\n<meta name=\"description\" content=\"Electric Literature of 20154-03-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 20154-03-4 name is 3-(Trifluoromethyl)-1H-pyrazole, This compound is widely used in many fields, so it is necessary to find a new synthetic route. 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