{"id":4457,"date":"2021-06-03T04:02:16","date_gmt":"2021-06-02T20:02:16","guid":{"rendered":"https:\/\/www.pyrazoles-derivatives.com\/?p=4457"},"modified":"2021-06-03T04:02:16","modified_gmt":"2021-06-02T20:02:16","slug":"discovery-of-c6h8n2o2","status":"publish","type":"post","link":"https:\/\/www.pyrazoles-derivatives.com\/?p=4457","title":{"rendered":"Discovery of  C6H8N2O2"},"content":{"rendered":"<p>Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 78703-53-4, name is 1,3-Dimethyl-1H-pyrazole-4-carboxylic acid, A new synthetic method of this compound is introduced below., <a href=\"https:\/\/www.ambeed.com\/products\/78703-53-4.html\">COA of Formula: C6H8N2O2<\/a><\/p>\n<p>To a solution of 10b (578.8 g, 4.13 mol) in DMAC (2.0 L) at 0 C was added thionyl chloride (514.7 g, 4.33 mol) dropwise, maintaining the temperature below 15 C. After addition of DMAC (0.25 L), the mixture was stirred at 0-15 C for 0.5 h. To this mixture was added 8 (500.0 g, 3.93 mol) portionwise, maintaining the temperature below 40 C. After addition of DMAC (0.75 L), the mixture was stirred at 15-40 C for 1 h. Then, H2O (1.0 L), NaOH (346.1 g, 8.65 mol) in H2O (4.5 L), and H2O (3.5 L) were successively added dropwise at 15-40 C. The resulting slurry was stirred for 2 h, and then filtered. Wet solids were washed with H2O (1.5 L) and dried in vacuo at 50 C to give the title compound 13b (923 g, 94%) as a pale brown solid; mp 188-189 C; 1H NMR (500 MHz, DMSO-d6) delta 2.19 (s, 3H), 3.98 (s, 3H), 6.62 (ddd, 4JHF=3.3 Hz, J=8.5, 3.3 Hz, 1H), 6.83 (s, 1H), 7.02 (dd, 4JHF=6.5 Hz, J=3.0 Hz, 1H), 7.07 (dd, 3JHF=10.0 Hz, J=9.0 Hz, 1H), 9.48 (br s, 1H), 9.85 (s, 1H); 13C NMR (125 MHz, DMSO-d6) delta 13.0, 38.5, 107.5, 112.9, 112.9, 115.8 (2JCF=21.3 Hz), 125.0 (2JCF=12.5 Hz), 135.2, 145.4, 149.0 (1JCF=235.0 Hz), 153.3 (3JCF=1.3 Hz), 158.0; IR (ATR) 3229, 1651, 1625, 1547, 1531, 1504, 1452, 1377, 1303, 1274, 1260, 1226, 1178, 1109, 1056, 1024, 973, 893, 850, 817, 804, 788, 771, 746, 678, 638, 624, 595, 527, 510, 461, 451, 432, 422, 412 cm-1; Anal. Calcd for C12H12N3O2F: C, 57.83; H, 4.85; N, 16.86. Found: C, 57.62; H, 4.69; N, 16.88.<\/p>\n<p>The synthetic route of 78703-53-4 has been constantly updated, and we look forward to future research findings.<\/p>\n<p>Reference:<br \/><a href=\"https:\/\/doi.org\/10.1016\/j.tet.2013.07.087\">Article; Ishimoto, Kazuhisa; Sawai, Yasuhiro; Fukuda, Naohiro; Nagata, Toshiaki; Ikemoto, Tomomi; Tetrahedron; vol. 69; 40; (2013); p. 8564 &#8211; 8571;<\/a>,<br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Pyrazole\">Pyrazole &#8211; Wikipedia<\/a>,<br \/><a href=\"https:\/\/www.sciencedirect.com\/topics\/chemistry\/pyrazoles\">Pyrazoles &#8211; an overview | ScienceDirect Topics<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The synthetic route of 78703-53-4 has been constantly updated, and we look forward to future research findings.<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[255,131],"tags":[126],"class_list":["post-4457","post","type-post","status-publish","format-standard","hentry","category-78703-53-4","category-pyrazoles-derivatives","tag-m-w100-200"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Discovery of<\/title>\n<meta name=\"description\" content=\"Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. 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